CPARs in the NAc protect against depression-like behaviors induced by chronic pain. CPARs in the NAc protect against depression-like behaviors induced.

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CPARs in the NAc protect against depression-like behaviors induced by chronic pain. CPARs in the NAc protect against depression-like behaviors induced by chronic pain. A, Experimental paradigm. B, Schematic showing tip of the injectors in the NAc. C, Naspm infusion into the NAc did not change mechanical hypersensitivity in SNI-operated rats. Student's t test, n = 9, p > 0.05. D, Naspm did not change cold hypersensitivity in SNI-operated rats. n = 9, p > 0.05. E, Naspm in the NAc reduced sucrose preference in SNI-treated rats, but it had no effects on the sucrose preference of sham-treated rats. Two-way ANOVA with Bonferroni post-test. n = 11, p < 0.05. F, Naspm in the NAc increased immobility in SNI-treated rats, but it did not alter immobility in sham-treated rats. Two-way ANOVA with Bonferroni post-test. n = 10–11, p < 0.05. G, Naspm did not alter locomotion in SNI-operated rats. Two-way ANOVA, n = 4–7, p > 0.05. Error bars show mean and SEM. Yossef Goffer et al. J. Neurosci. 2013;33:19034-19044 ©2013 by Society for Neuroscience