The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease Ingram Schulze-Neick,

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Presentation transcript:

The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease Ingram Schulze-Neick, MD, Jia Li, MD, Jayne A. Reader, Lara Shekerdemian, MD, Andrew N. Redington, MD, Daniel J. Penny, MD The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 3, Pages 435-441 (September 2002) DOI: 10.1067/mtc.2002.121492 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Hemodynamic variables during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicated as follows: *P <.05 and **P <.01. NS, Not significant; inhNO, inhaled NO. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 435-441DOI: (10.1067/mtc.2002.121492) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Metabolic variables and derived cardiac output during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicated as follows: *P <.05 and **P <.01. NS, Not significant; inhNO, inhaled NO. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 435-441DOI: (10.1067/mtc.2002.121492) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Vascular resistance during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicated as follows: *P <.05 and **P <.01. NS, Not significant; inhNO, inhaled NO. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 435-441DOI: (10.1067/mtc.2002.121492) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Correlation of plasma endothelin levels and PVR response to ETA blockade. The arterial ET-1 concentration is related to the decrease of PVR in response to BQ123 infusion (r2 = 0.89, P <.05). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 435-441DOI: (10.1067/mtc.2002.121492) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions