Ross T. Lyon, M. D. , Arthur Runyon-Hass, Ph. D. , Harry R. Davis, Ph

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Presentation transcript:

Protection from atherosclerotic lesion formation by reduction of artery wall motion Ross T. Lyon, M.D., Arthur Runyon-Hass, Ph.D., Harry R. Davis, Ph.D., Seymour Glagov, M.D., Christopher K. Zarins, M.D. Journal of Vascular Surgery Volume 5, Issue 1, Pages 59-67 (January 1987) DOI: 10.1016/0741-5214(87)90195-9 Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Representative aortogram of cynomolgus monkey 3 months after coarctation. Average stenosis was 76% ± 2% corresponding to terminal gradient of 25 ± 1 mm Hg. Journal of Vascular Surgery 1987 5, 59-67DOI: (10.1016/0741-5214(87)90195-9) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Representative histologic appearance of diet-induced lesions in proximal (A) and distal (B) thoracic aorta in animals without coarctation after 3 months on an atherogenic diet. Lesions in both locations are several foam cells thick. ▶ indicates internal elastic lamina. (Methylene blue basic fuchsin stain; original magnification × 625.) Journal of Vascular Surgery 1987 5, 59-67DOI: (10.1016/0741-5214(87)90195-9) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Representative histologic appearance of diet-induced lesions proximal and distal to coarctation in the operated animals. A, Above stenosis intimal lesions are thick and contain abundant foam cells as well as smooth muscle cells and matrix fibers. B, Distal to stenosis intima is not thickened and no foam cells or smooth muscle cells are evident. ▶ indicates internal elastic lamina. (Methylene blue basic fuchsin stain; original magnification × 350.) Journal of Vascular Surgery 1987 5, 59-67DOI: (10.1016/0741-5214(87)90195-9) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions