Sensitivity analysis of cellular responses to perturbation of the DNA damage response signaling in the presence of chemotherapies. Sensitivity analysis.

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Presentation transcript:

Sensitivity analysis of cellular responses to perturbation of the DNA damage response signaling in the presence of chemotherapies. Sensitivity analysis of cellular responses to perturbation of the DNA damage response signaling in the presence of chemotherapies. (A and B) For the chemotherapies, a low dose of 0.001 μM (A) and a high dose of 1 μM (B) were simulated. The inhibition of eight molecular targets within the DNA damage response pathway (ATM, ATR, DNA-PK, CHK1, CHK2, p53, p21, and CHK1/2) was simulated. The effect of chemotherapies is simulated as monotherapy or in combination (bars) and shown on the x axis. The outcome is quantified as log10 fold change of cell number after 3 days of the drug exposure. The vertical dashed line is aligned to the effect of the chemotherapy alone (first bar in each and dashed lines), which is the comparator for the effect of the combinations. Ozan Alkan et al., Sci. Signal. 2018;11:eaat0229 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works