Evidence for Autosomal Dominant Inheritance of Prostate Cancer

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Presentation transcript:

Evidence for Autosomal Dominant Inheritance of Prostate Cancer Daniel J. Schaid, Shannon K. McDonnell, Michael L. Blute, Stephen N. Thibodeau The American Journal of Human Genetics Volume 62, Issue 6, Pages 1425-1438 (June 1998) DOI: 10.1086/301862 Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 1 Cumulative risk of prostate cancer among first-degree relatives, according to age at diagnosis of the proband. Cumulative risks were estimated by nonparametric Kaplan-Meier methodology. The American Journal of Human Genetics 1998 62, 1425-1438DOI: (10.1086/301862) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 2 Predicted cumulative risk of prostate cancer for carriers and noncarriers, based on autosomal dominant models for subsets defined by age at diagnosis of the proband: <60, 60–69, and ⩾70 (70+) years. The American Journal of Human Genetics 1998 62, 1425-1438DOI: (10.1086/301862) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 3 Cumulative risk of prostate cancer among fathers and brothers of probands who were diagnosed at age <60 years (Kaplan-Meier estimates), and predicted risk based on the autosomal dominant–model parameters given in table 5. The American Journal of Human Genetics 1998 62, 1425-1438DOI: (10.1086/301862) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 4 Cumulative risk of prostate cancer among fathers and brothers of probands who were diagnosed at age 60–69 years (Kaplan-Meier estimates), and predicted risk based on the autosomal dominant–model parameters given in table 5. The American Journal of Human Genetics 1998 62, 1425-1438DOI: (10.1086/301862) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 5 Cumulative risk of prostate cancer among fathers and brothers of probands who were diagnosed at age ⩾70 years (Kaplan-Meier estimates), and predicted risk based on the autosomal dominant–model parameters given in table 5. The American Journal of Human Genetics 1998 62, 1425-1438DOI: (10.1086/301862) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 6 Comparison of the best-fitting dominant model, assuming HWE, between the Mayo Clinic data (Mayo) and the JHU data (Carter et al. 1992). The American Journal of Human Genetics 1998 62, 1425-1438DOI: (10.1086/301862) Copyright © 1998 The American Society of Human Genetics Terms and Conditions