Percent signal change in subcortical ROIs Percent signal change in subcortical ROIs. Mean percent signal change was calculated for each of the four trial types in four anatomically defined subcortical ROIs: caudate (a), putamen (b), thalamus (c), and superior colliculus (d) in left (solid bars) and... Percent signal change in subcortical ROIs. Mean percent signal change was calculated for each of the four trial types in four anatomically defined subcortical ROIs: caudate (a), putamen (b), thalamus (c), and superior colliculus (d) in left (solid bars) and right (striped bars) hemispheres. Percent signal change was averaged across participants. Error bars indicate SEM. Katharine N. Thakkar et al. J. Neurosci. 2014;34:8918-8929 ©2014 by Society for Neuroscience