Ventricular fibrogenesis activity assessed by serum levels of procollagen type III N- terminal amino peptide during the staged Fontan procedure Masaya.

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Presentation transcript:

Ventricular fibrogenesis activity assessed by serum levels of procollagen type III N- terminal amino peptide during the staged Fontan procedure Masaya Sugimoto, MD, Hirofumi Saiki, MD, Akiko Tamai, MD, Mitsuru Seki, MD, Ryo Inuzuka, MD, Satoshi Masutani, MD, Hideaki Senzaki, MD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 6, Pages 1518-1526 (June 2016) DOI: 10.1016/j.jtcvs.2016.01.020 Copyright © 2016 Terms and Conditions

Figure 1 Relationship between serum PIIIP levels and age in control patients (n = 149). PIIIP, Amino-terminal procollagen type III. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1518-1526DOI: (10.1016/j.jtcvs.2016.01.020) Copyright © 2016 Terms and Conditions

Figure 2 A, Serum PIIIP levels for each group. Bars represent the mean values. B, Serial changes in PIIIP levels in the BTS/PAB, Glenn, and Fontan groups. †P < .05 versus controls (right shoulder) and between the 2 groups stratified according to age (above the bars). PIIIP, Amino-terminal procollagen type III; BTS/PAB, blalock–Taussig shunt/pulmonary artery banding. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1518-1526DOI: (10.1016/j.jtcvs.2016.01.020) Copyright © 2016 Terms and Conditions

Figure 3 A, The relationship between serum PIIIP levels and Qp/Qs in patients in the BTS or PAB group. B, Expected mean PIIIP levels (black dotted line) and 95% confidence interval of mean PIIIP levels (red dotted line) as a function of Qp/Qs based on random forests regression analysis. PIIIP, Amino-terminal procollagen type III; Qp/Qs, pulmonary-to-systemic blood flow. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1518-1526DOI: (10.1016/j.jtcvs.2016.01.020) Copyright © 2016 Terms and Conditions

Figure 4 Relationship between PIIIP levels and EDP (n = 32) (A) and ventricular stiffness (n = 22) (B) in the Fontan group. Relationship between PIIIP levels and RAS in the Fontan group (C-E). PIIIP, Amino-terminal procollagen type III; EDP, end-diastolic pressure. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1518-1526DOI: (10.1016/j.jtcvs.2016.01.020) Copyright © 2016 Terms and Conditions

Figure 5 Relationship between pre-Fontan PIIIP levels and post-Fontan ventricular EDP. PIIIP, Amino-terminal procollagen type III; EDP, end-diastolic pressure. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1518-1526DOI: (10.1016/j.jtcvs.2016.01.020) Copyright © 2016 Terms and Conditions

PIIIP levels are associated with ventricular diastolic dysfunction. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1518-1526DOI: (10.1016/j.jtcvs.2016.01.020) Copyright © 2016 Terms and Conditions