Clustergram of genes induced at 2 h after the end of treatment with 50 cGy γ-rays delivered at either (1) 290 cGy/min, (2) 29 cGy/min, (3) 2.4 cGy/min,

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Clustergram of genes induced at 2 h after the end of treatment with 50 cGy γ-rays delivered at either (1) 290 cGy/min, (2) 29 cGy/min, (3) 2.4 cGy/min, or (4) 0.28 cGy/min. Clustergram of genes induced at 2 h after the end of treatment with 50 cGy γ-rays delivered at either (1) 290 cGy/min, (2) 29 cGy/min, (3) 2.4 cGy/min, or (4) 0.28 cGy/min. Array data have been filtered to include only induced genes with significant hybridization above background, area greater than 20 pixels, and overall quality greater than 0.5 as determined by analysis with ArraySuite 2.1. The dendrogram at the top of the figure indicates the relative relationships between the four different treatment conditions as determined by the Clustering Online program [National Human Genome Research Institute (NHGRI)]. The darker red squares indicate low or absent gene induction, while the brighter the red, the larger the relative gene induction. The genes in the region marked A generally show a significant response only to acute exposure. Region B is a cluster of genes exhibiting dose rate-independent regulation, while the genes in region C show a marked dose rate-dependent regulation. An enlargement of the candidates for dose rate-independent regulation is also shown with the genes examined in greater detail listed in boldface. (See also Table 1.)‏ Sally A. Amundson et al. Mol Cancer Res 2003;1:445-452 ©2003 by American Association for Cancer Research