Photomicrograph from a retinoblastoma showing multiple Flexner-Wintersteiner rosettes. Photomicrograph from a retinoblastoma showing multiple Flexner-Wintersteiner.

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Photomicrograph from a retinoblastoma showing multiple Flexner-Wintersteiner rosettes. Photomicrograph from a retinoblastoma showing multiple Flexner-Wintersteiner rosettes. The halo-like cluster of cells in each rosette surrounds a nearly empty appearing central lumen containing fine cytoplasmic processes (H&E; original magnification 400×). Photomicrograph generously donated by Dr. Morton Smith, Ophthalmic Pathology, Washington University, St. Louis. F.J. Wippold II, and A. Perry AJNR Am J Neuroradiol 2006;27:488-492 ©2006 by American Society of Neuroradiology