Type I and III IFNR expression on hematopoietic cells is required for protection against IA. Type I and III IFNR expression on hematopoietic cells is required.

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Type I and III IFNR expression on hematopoietic cells is required for protection against IA. Type I and III IFNR expression on hematopoietic cells is required for protection against IA. (A and B) Lethally irradiated recipients were reconstituted with donor bone marrow (BM) for 8 weeks before infection with 8 × 107 CEA10 Af conidia. (A) Kaplan-Meier survival plot for eight mice per group analyzed in two independent experiments. (B) Representative images of Gomori ammoniacal silver–stained lung sections captured at ×40 magnification. (C) Western blot analysis of STAT1 phosphorylation at 15 min after treatment with 100 ng of recombinant murine IFN-α2 or mIFN-λ2 as indicated. Bone marrow neutrophils from each experimental group were FACS-sorted (>99% purity) before in vitro treatment with IFNs. (D and E) Neutrophils from the bone marrow, spleen, or lung of WT mice (D) and IFNLR1−/− mice (E) were FACS-sorted (>99% purity) before in vitro treatment with IFNs and examined for responsiveness by Western blot analysis of STAT1 phosphorylation. Neutrophils were sorted as Live CD45+CD11b+Ly6CintLy6G+. Vanessa Espinosa et al. Sci. Immunol. 2017;2:eaan5357 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works