Fig. 4 Cdc42 enhances the cellular uptake of EVs.

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 2 The SOS response is required for persistence to ofloxacin but not prior treatment. The SOS response is required for persistence to ofloxacin but.

Fig. 5 MicroLED array with 3D liquid metal interconnects.

Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 2 Boronic acid–rich dendrimer in cytosolic delivery.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 1 Pump-probe signatures of vermilion (red HgS), black HgS, and metallic Hg. Pump-probe signatures of vermilion (red HgS), black HgS, and metallic.

Fig. 3 Oil, gas, and FP water variations with time.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 1 NP-free Ch-CNC droplets.

Fig. 6 Different models of assembly of Ch-CNC droplets laden with Fe3O4NPs under magnetic field. Different models of assembly of Ch-CNC droplets laden.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 2 Reference-fixing experiment, results.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 1 The structure of the 3DGraphene foam.

Fig. 3 Gate voltage dependence of the areal iDMI and PMA.

Fig. 1 Distribution of total and fake news shares.

Fig. 2 2D QWs of different propagation lengths.

Fig. 2 ODN enhances EV transfer between cells expressing TLR9.

Electronic structure of the oligomer (n = 8) at the UB3LYP/6-31G

Fig. 1 EVs transport ODN into recipient cells.

Fig. 6 WPS imaging of different chemical components in living cells.

Fig. 3 Proteomic analysis and Western blot analysis of protein cargos of various EVs. Proteomic analysis and Western blot analysis of protein cargos of.

Fig. 4 DFT ωB97x/def2-TZVPP atomic charges on the sulfur atom of substituted thioaldehyde and AIMNet prediction with a different number of iterative passes.

Fig. 6 Caspase-3– and -7–deficient cells maintain mitochondrial membrane polarity following intrinsic or extrinsic apoptotic stimuli. Caspase-3– and -7–deficient.

Fig. 5 Simultaneous absence of caspase-3 and -7 is required for significant decrease of caspase-8 and -9 activation in intrinsic apoptosis. Simultaneous.

Fig. 4 Activation of mitochondrial apoptosis pathway by n-HA.

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 1 IDH3α expression is elevated in human-derived gliomas.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Characteristics of ultrathin single-crystalline semiconductor films

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 SPICE simulation of stochasticity.

Fig. 2 NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ clean air policy. NH3, NOx, SO2, and NMVOC emission changes triggered by the JJJ.

Release of phototethered siRNA from the hydrogels and RNA bioactivity

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Schematic of the proposed brain-controlled assistive hearing device

Fig. 1 Experimental strategy and elemental and morphological analysis of 3D/2D perovskite bilayer. Experimental strategy and elemental and morphological.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 2 Simulations of possible doping positions and band structures.

Fig. 1 Structural and electrical properties of Bi2Se3/BaFe12O19.

Fig. 2 Mean field results. Mean field results. (A) Solutions P(x) to Eq. 4 for a range of T and wc = (B) Modulus ∣pk∣ of order parameters versus.

Fig. 6 Stabilization of hippocampal signaling over sleep.

Fig. 3 Effects of ASO and eGLP1-ASO conjugates on gene expression and protein levels in vitro in cell lines and primary mouse islet cells. Effects of ASO.

Fig. 3 Heterologous TRPV1-mediated uptake of gentamicin is attenuated by extracellular [Ca2+]. Heterologous TRPV1-mediated uptake of gentamicin is attenuated.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 1 RNA methyltransferase METTL14 and demethylase ALKBH5 promote growth and invasion of breast cancer cells. RNA methyltransferase METTL14 and demethylase.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Supraballs and films assembled from binary 219/217nm SPs/SMPs.

Fig. 2 Supraballs and films from binary SPs.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 1 Schematic structure of a fluorescently labeled eGLP1-conjugated MALAT1 ASO and internalization of fluorescent eGLP1 and eGLP1-MALAT1-ASO. Schematic.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 1 Design principle and SEM characterization of super-origami DNA nanostructures with n-tuples. Design principle and SEM characterization of super-origami.

Fig. 1 Overview of amber clast with synchrotron x-ray μCT image of articulated snake skeleton (DIP-S-0907). Overview of amber clast with synchrotron x-ray.

Fig. 4 Systemic AAV9 delivery of gene editing components to ΔEx44 mice rescues dystrophin expression. Systemic AAV9 delivery of gene editing components.

Fig. 5 Phototransduction mechanisms.

Fig. 1 Doping schematics and optical properties.

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 3 Calculated electronic structure of ZrCoBi.

Presentation transcript:

Fig. 4 Cdc42 enhances the cellular uptake of EVs. Cdc42 enhances the cellular uptake of EVs. (A) Western blot analysis of the level of Cdc42 in cells expressing Cdc42Q61L. (B) Confocal images of reporter+ cells expressing Cdc42. In the Cre-LoxP reporter system (see Fig. 1A), Cre+ cells were cocultured with reporter+ cells for 48 hours after the transfection of Cdc42Q61L plasmid. Scale bars, 100 μm. (C) Western blot analysis of the level of Cdc42 in reporter+ cells, which were treated with 0, 50, or 100 nM Cdc42 small interfering RNA (siRNA) for 48 hours. (D) Confocal microscopy images of reporter+ cells. Both Cre+ cells and reporter+ cells were treated with 100 nM Cdc42 siRNA. After 6 hours, the medium was replaced with fresh medium. Then, Cre+ cells were treated with 0.5 μM ODN or 20 μM GW4869 for 24 hours before being mixed with reporter+ cells. After 24 hours, cells were observed by confocal microscopy. Scale bars, 50 μm. Graphs in (B) and (D) represent the percentage of reporter+ cells with GFP signals and show means ± SEM. [**P < 0.01 using unpaired Student’s t test (B); *P < 0.05 using ANOVA one-way test (D)]. The percentage of cells with GFP signals was calculated in three different fields of each condition. Images are representative of at least three independent experiments. Ying Zhang et al. Sci Adv 2019;5:eaav1564 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).