PTENP1 expression is downregulated in ccRCC.

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Presentation transcript:

PTENP1 expression is downregulated in ccRCC. PTENP1 expression is downregulated in ccRCC. A, PTENP1 expression levels were evaluated by real-time PCR in nontumorigenic renal cell line HK-2, renal cancer cell lines, and paired case specimens. B, methylation-specific PCR was performed using primers specific for the unmethylated (U) or methylated (M) PTENP1 promoter region in the genomic DNA deriving from renal cell lines or renal cancer tissues. NC, unmethylated genomic DNA; PC, methylated genomic DNA. C, PTENP1 expression in 5 renal cancer cell lines after 5AZA-C or mock treatment. *, P < 0.05; **, P < 0.01. D, the expression of PTEN and PTENP1 in renal cancer tissues and normal control tissues. The expression of PTEN and PTENP1 is lower in cancer tissues than normal controls. The expression of PTEN and PTENP1 in cancer tissues includes positive correlation (P < 0.01; R2 = 0.6374). E, PTEN protein levels were determined by immunoblot analysis in renal cancer cell line ACHN and SN12PM6 after being infected with Lenti-PTENP1 or Lenti-NC. Gan Yu et al. Mol Cancer Ther 2014;13:3086-3097 ©2014 by American Association for Cancer Research