Christopher Hazzard, BS, Andrea S. Wolf, MD, Mary B

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Presentation transcript:

Benign Imitation of Malignancy: Avoiding Resection in Immunoglobulin G4–Related Lung Disease Christopher Hazzard, BS, Andrea S. Wolf, MD, Mary B. Beasley, MD, Raja M. Flores, MD The Annals of Thoracic Surgery Volume 98, Issue 4, Pages 1465-1467 (October 2014) DOI: 10.1016/j.athoracsur.2013.11.079 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Computed tomographic scan showing a 3.7-cm spiculated mass with postobstructive atelectasis in the right lower lobe. The Annals of Thoracic Surgery 2014 98, 1465-1467DOI: (10.1016/j.athoracsur.2013.11.079) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 18Fluorodeoxyglucose positron emission tomography/computed tomography demonstrating hypermetabolism of the mass with a maximum standardized uptake value of 9.9. The Annals of Thoracic Surgery 2014 98, 1465-1467DOI: (10.1016/j.athoracsur.2013.11.079) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Low-power view of mass showing collagenous fibrosis with admixed inflammatory cells. (Hematoxlyin and eosin [H&E], ×40.) (B) Areas of fibrosis consisting of dense collagen. (H&E, ×200.) (C) Areas of fibrosis with higher cellularity consisting of inflammatory cells and spindle cells with a vague storiform growth pattern. (H&E, ×200.) (D) Blood vessels showing partial obliteration by the fibroinflammatory process. (H&E, ×200.) (E) Inflammatory cell infiltrate containing numerous plasma cells. (H&E, ×400.) (F) Plasma cells were positive for immunoglobulin G4 (IgG4) in numbers greater than 50 per single high-power field. (IgG4 immunostain, ×400.) The Annals of Thoracic Surgery 2014 98, 1465-1467DOI: (10.1016/j.athoracsur.2013.11.079) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions