Uptake of diazepam (1 μM; A and E), pitavastatin (1 μM; B and F), rosuvastatin (1 μM; C and G), and pravastatin (1 μM; D and H) by human hepatocytes measured.

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Uptake of diazepam (1 μM; A and E), pitavastatin (1 μM; B and F), rosuvastatin (1 μM; C and G), and pravastatin (1 μM; D and H) by human hepatocytes measured after incubation at 37°C for 0.5–60 minutes. Uptake of diazepam (1 μM; A and E), pitavastatin (1 μM; B and F), rosuvastatin (1 μM; C and G), and pravastatin (1 μM; D and H) by human hepatocytes measured after incubation at 37°C for 0.5–60 minutes. (A–D) Cryopreserved human hepatocytes from a single donor (Lot Hu8075) were used. (E–H) Pooled cryopreserved human hepatocytes from 20 mixed-sex donors (Lot TFF) were used. The data are presented as mean + S.D. (n = 3). Takashi Yoshikado et al. Drug Metab Dispos 2017;45:779-789 Copyright © 2017 by The Author(s)‏