Volume 80, Issue 10, Pages (November 2011)

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Presentation transcript:

Volume 80, Issue 10, Pages 1099-1106 (November 2011) Renal tubular dysfunction in patients with American cutaneous leishmaniasis Rodrigo A. de Oliveira, Lúcyo F.B. Diniz, Leonardo O. Teotônio, Cláudio G. Lima, Rosa M.S. Mota, Alice Martins, Talita R. Sanches, Antônio C. Seguro, Lúcia Andrade, Geraldo B. Silva, Alexandre B. Libório, Elizabeth F. Daher Kidney International Volume 80, Issue 10, Pages 1099-1106 (November 2011) DOI: 10.1038/ki.2011.251 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Urine concentration and acidification capacity in ACL patients pre- and post-desmopressin test and pre- and post-CaCl2 test. (a) Uosm pre- and post-desmopression test in ACL patients with normal or abnormal urinary concentration. (b) UpH pre- and post-CaCl2 test in ACL patients with normal or abnormal urinary acidification. ACL, American cutaneous leishmaniasis; NS, nonsignificant; Uosm, urine osmolality; UpH, urinary pH. Kidney International 2011 80, 1099-1106DOI: (10.1038/ki.2011.251) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 2 Western blotting analysis in the urinary exosome fraction, normalized to urinary creatinine, in controls and in patients with ACL. Abundance of (a) AQP2 and (b) NKCC2. ACL, American cutaneous leishmaniasis; AQP2, aquaporin 2; NKCC2, Na-K-2Cl cotransporter. Kidney International 2011 80, 1099-1106DOI: (10.1038/ki.2011.251) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 3 Abundance of NHE3 by western blotting analysis in the urinary exosome fraction, normalized to urinary creatinine, in controls and in patients with ACL. ACL, American cutaneous leishmaniasis; NHE3, Na/H exchanger. Kidney International 2011 80, 1099-1106DOI: (10.1038/ki.2011.251) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 4 Western blotting analysis in the urinary exosome fraction, normalized to urinary creatinine, in controls and in patients with ACL. Abundance of (a) H+-ATPase and (b) pendrin. ACL, American cutaneous leishmaniasis. Kidney International 2011 80, 1099-1106DOI: (10.1038/ki.2011.251) Copyright © 2011 International Society of Nephrology Terms and Conditions