Transforming growth factor–β overexpression in cutaneous extramedullary hematopoiesis of a patient with myelodysplastic syndrome associated with myelofibrosis

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Transforming growth factor–β overexpression in cutaneous extramedullary hematopoiesis of a patient with myelodysplastic syndrome associated with myelofibrosis Tamihiro Kawakami, MD, PhD, Satoko Kimura, MD, PhD, Masayuki Kato, MD, PhD, Masako Mizoguchi, MD, PhD, Yoshinao Soma, MD, PhD Journal of the American Academy of Dermatology Volume 58, Issue 4, Pages 703-706 (April 2008) DOI: 10.1016/j.jaad.2007.10.489 Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Multiple skin-colored, partial red, dermal and subcutaneous firm nodules over front aspect of trunk. Journal of the American Academy of Dermatology 2008 58, 703-706DOI: (10.1016/j.jaad.2007.10.489) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, Biopsy specimen of skin nodule showed aggregates of hematopoietic cells within extramedullary hematopoiesis mass in dermis and around blood vessels and appendageal area. All 3 marrow elements (myeloid, erythroid, and megakaryocytic series) were present in skin lesions. (A, Hematoxylin-eosin stain; original magnification: ×40; inset, ×200.) B, Immunohistochemistry for CD31 revealed megakaryocytes showing atypical features. C, Immunohistochemistry for myeloperoxidase revealed numerous myeloid progenitors, granulopoietic cells. (B and C, Original magnifications: ×400.) Journal of the American Academy of Dermatology 2008 58, 703-706DOI: (10.1016/j.jaad.2007.10.489) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 A, Immunohistochemical staining for transforming growth factor (TGF)-β1 in cutaneous extramedullary hematopoiesis (EMH). Overexpression of immunoreactive TGF-β1 was present in immature hematopoietic cells and dermal fibroblasts within cutaneous EMH mass. B, Negative control. (Original magnification: ×400.) Journal of the American Academy of Dermatology 2008 58, 703-706DOI: (10.1016/j.jaad.2007.10.489) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions