FTY720 protects WM and motor development after neonatal LPS/HI injury.

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FTY720 protects WM and motor development after neonatal LPS/HI injury. FTY720 protects WM and motor development after neonatal LPS/HI injury. A, MEMRI comparison at 24 h recovery. Note the disappearance of cytoarchitectural distinctions in the ipsilateral hemisphere (asterisk) in saline-treated, but not FTY720-treated, rats (n = 4–5 for each group). B, Comparison of ADC at 24 h after LPS/HI. Note the reduction of ADC signals in the ipsilateral hemisphere in saline-treated animals (asterisk). Sodium MRI acquisition and quantification showed spatial correlation between increased sodium concentration and reduced ADC signal. The LPS/HI injury also caused shifting of sodium toward the ipsilateral hemisphere. C, Representative in vivo DTI image of saline- and FTY720-treated animals at 24 h recovery of LPS/HI injury. The TBSS detected regions with p < 0.05 difference in mean diffusivity (in gray matter) and FA (WM) between saline-treated (n = 5) and FTY720-treated (n = 4) animals at 24 h after LPS/HI injury. D, Representative in vivo diffusion tensor image of saline- and FTY720-treated rat pups at 14 d recovery. E, Quantification showed significant preservation of ADC signals in the cerebral cortex of FTY720-treated rat pups (n = 8) when compared with those receiving the saline treatment (n = 9). F, Comparison of the latency to fall (seconds) on rotarods in untouched (UN), LPS/HI-injured and saline- or FTY720-treated rat pups at 24 d of age (n = 3 for untouched, 8 each for saline- and FTY720-treated animals). G, Comparison of the body weight of untouched, LPS/HI-injured, and saline- or FTY720-treated rats pups at 24 d of age (n = 3 for untouched, 8 for saline- or FTY720-treated animals). Cont, Contralateral; Ipsi, ipsilateral. Dianer Yang et al. J. Neurosci. 2014;34:16467-16481 ©2014 by Society for Neuroscience