Smad1 induces target genes in conditioned DRG neurons.

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Smad1 induces target genes in conditioned DRG neurons. Smad1 induces target genes in conditioned DRG neurons. A, Representative immunohistochemistry images and quantification of pSmad1+ neurons in L5 DRG 6 h and 3 d after either sciatic nerve (SNL) or dorsal column lesion (DCL), with control DRGs from contralateral (Contra) or mice with laminectomy only (Sham) (n = 3 mice each). Scale bar, 50 μm. B, Western blot using DRG lysates from Smad1 cKO mice or littermate controls probed for Smad1 or H3 (as loading control). C, qRT-PCR results of RAGs from mRNA extracted from freshly dissected DRGs from Smad1 cKO or littermate control mice. D, Human, mouse, and rat RAGs promoter sequences are aligned and conserved GC-rich SBEs are highlighted in gray. Data are mean ± SEM. *p < 0.05. **p < 0.01. ***p < 0.001. Mattéa J. Finelli et al. J. Neurosci. 2013;33:19664-19676 ©2013 by Society for Neuroscience