Predictive factors of failure in management of ectopic pregnancy with single-dose methotrexate: a general population-based analysis from the Auvergne Register, France  Benoit Rabischong, M.D., Xavier Tran, M.D., Aline Abi Sleiman, M.D., Demetrio Larraín, M.D., Patricia Jaffeux, Bruno Aublet-Cuvelier, M.D., Ph.D., Jean-Luc Pouly, M.D., Hervé Fernandez, M.D., Ph.D.  Fertility and Sterility  Volume 95, Issue 1, Pages 401-404.e1 (January 2011) DOI: 10.1016/j.fertnstert.2010.08.025 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Receiver operating characteristic curve of initial hCG level >1,300 IU/L in predicting failure of single-dose MTX in the treatment of EP. Sensitivity and the false-positive rate (100-specificity) are correlated. Calculated from 103 failures and 316 cases treated successfully with MTX. The diagonal line illustrates a diagnostic test with no predictive value. The area under the receiver operating characteristic curve was 0.67 (95% CI 0.63–0.72) (P<.0001). The sensitivity and specificity were 55% (95% CI 44.7–65) and 74% (95% CI 68.7–78.7), respectively. The positive and negative likelihood ratios were 2.1 and 0.6, respectively. Fertility and Sterility 2011 95, 401-404.e1DOI: (10.1016/j.fertnstert.2010.08.025) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions