17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma.

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Presentation transcript:

17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry James H. Flory, MD, MS, Patrick M. Sleiman, PhD, Jason D. Christie, MD, MS, Kiran Annaiah, MSc, Jonathan Bradfield, BS, Cecilia E. Kim, BA, Joseph Glessner, MSc, Marcin Imielinski, MD, PhD, Hongzhe Li, PhD, Edward C. Frackelton, BA, Hou Cuiping, PhD, George Otieno, MSc, Kelly Thomas, BA, Ryan Smith, BA, Wendy Glaberson, BA, Maria Garris, BA, Rosetta Chiavacci, MSc, Julian Allen, MD, Jonathan Spergel, MD, PhD, Robert Grundmeier, MD, PhD, Michael Grunstein, MD, PhD, Michael Magnusson, MD, PhD, Struan F.A. Grant, PhD, Klaus Bønnelykke, MD, Hans Bisgaard, MD, Hakon Hakonarson, MD, PhD Journal of Allergy and Clinical Immunology Volume 124, Issue 3, Pages 605-607 (September 2009) DOI: 10.1016/j.jaci.2009.05.047 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Odds ratios for association of rs7216389 with pediatric asthma and 95% CIs (y-axis) in ordered subsets of maximum age of onset (x-axis). Only data for white subjects are shown. Journal of Allergy and Clinical Immunology 2009 124, 605-607DOI: (10.1016/j.jaci.2009.05.047) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions