GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone AGSTZ1 mRNA expression in HCC and paired non‐tumor.

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GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone AWestern blotting shows endogenous GSTZ1‐1 protein.

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GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone AGSTZ1 mRNA expression in HCC and paired non‐tumor tissues from The Cancer Genome Atlas (TCGA) Liver Hepatocellular Carcinoma (LIHC) dataset. BGSTZ1 mRNA expression in increasing pathologic stages of HCC based on data from TCGA database. The box‐and‐whisker plots display the medians (horizontal lines), interquartile ranges (boxes), and minimum and maximum values (whiskers) of the mRNA expression data. The n indicates the number of samples. COverall survival of HCC patients with high (> 25 percentile) or low (≤ 25 percentile) mRNA expression of GSTZ1‐1, based on TCGA data. D, EGSTZ1 mRNA (D) and protein (E) expression in 40 cases of HCC and paired non‐tumor tissues. FRepresentative images (left) and quantification (right) of GSTZ1‐1 immunohistochemical staining in 12 cases of HCC and paired non‐tumor tissues. Scale bars: 100 μm. Data information: **P < 0.01, ***P < 0.001, Student's t‐test (A, D, and F) or one‐way ANOVA followed by the Tukey test (B) or Gehan–Breslow–Wilcoxon test (C). Abbreviations: N, non‐tumor; T, tumor; RPKM, reads per kilobase per million mapped reads; RSEM, RNA sequencing by expectation maximization.Source data are available online for this figure. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO J, Volume: 38, Issue: 15, First published: 28 June 2019, DOI: (10.15252/embj.2019101964)