Gene expression changes in the PFC of mice with decreased TrkB expression. Gene expression changes in the PFC of mice with decreased TrkB expression. A-I,

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Gene expression changes in the PFC of mice with decreased TrkB expression. Gene expression changes in the PFC of mice with decreased TrkB expression. A-I, Representative autoradiograms illustrating TrkB (A-C), GAD67 (D-F), and PV (G-I) mRNA expression in a wild-type mouse (left), a mouse heterozygous for the fBZ locus (fBZ/+) (middle), and a mouse homozygous for the fBZ locus (fBZ/fBZ) (right) in adulthood. The densities of hybridization signals are presented in a pseudocolor manner according to the calibration scales (right) for each mRNA. Note that TrkB mRNA is expressed in proportion to the gene dose (A-C). GAD67 and PV mRNA expression levels appear to be decreased in the PFC of the fBZ/fBZ mouse (F, I), in which the expression of TrkB mRNA is remarkably decreased (C). The arrowheads in A-C indicate the quantified regions in the PFC (applies to all sections from each mouse). Scale bar (in I), 1 mm. J-L, Mean ± SD expression levels of TrkB (J), GAD67 (K), and PV (L) mRNAs in the PFC of adult mice with wild-type, fBZ/+, or fBZ/fBZ genotypes. M-O, Mean ± SD neuronal density (M), GAD67 mRNA-positive neuron density (N), and GAD67 mRNA expression per positive neuron (O). Bars not sharing the same alphabetical letter are statistically different (p < 0.05; post hoc Tukey's multiple comparison). Takanori Hashimoto et al. J. Neurosci. 2005;25:372-383 ©2005 by Society for Neuroscience