Histopathologic characteristics in HL-mice and HL-HPS-mice.

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Histopathologic characteristics in HL-mice and HL-HPS-mice. Histopathologic characteristics in HL-mice and HL-HPS-mice. H&E staining (A) and Fontana–Masson staining (B) of epithelia from HL-mice and HL-HPS-mice are presented. Melanin with brown color (right photograph in A) and black color (B) was detected. C, percentages (mean ± SD) of melanin density (melanin-containing area per measured area) in the epithelia from HL-mice and HL-HPS-mice were analyzed by the software program WinROOF after Fontana–Masson staining. **, significantly different (P < 0.01) from the control by the Mann–Whitney U test. Masashi Kato et al. Cancer Epidemiol Biomarkers Prev 2011;20:1622-1628 ©2011 by American Association for Cancer Research