Peripheral CAF model. Peripheral CAF model. A, bright field (top) and fluorescence (bottom) micrographs of aggregates that contain RFP-tagged 344SQ cells.

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Peripheral CAF model. Peripheral CAF model. A, bright field (top) and fluorescence (bottom) micrographs of aggregates that contain RFP-tagged 344SQ cells alone (344SQ) or with untagged CAFs (344SQ + CAF) in the presence or absence of GM6001. Arrows, projections of invasive tumor cells. Bar size, 100 μm. B, percentages of total aggregates (n = 200 aggregates counted per condition) scored as invasive or noninvasive in the presence or absence of GM6001. Daniela Pankova et al. Mol Cancer Res 2016;14:287-295 ©2016 by American Association for Cancer Research