Figure 3. Enhancement of cytokine production by CD8+ T cells at TT

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Figure 3. Enhancement of cytokine production by CD8+ T cells at TT Figure 3. Enhancement of cytokine production by CD8+ T cells at TT. Tumor bearing mice had aquatic exercise (n=9 per group) and 3 mice were randomly sacrificed every wk after aquatic exercise. Splenocytes were isolated from housing and aquatic exercise (at TT and BT) groups of mice for 3 weeks and were stimulated for 4 h with PMA and ionomycin to assess for T cell functional activity. (A) Frequency of IFNγ-, IL-4- and IL-17-producing CD4+ T cells. Data are representative for 2 independent experiments with three mice per group. (B and C) IFNγ expression of CD8+ T cells in housing and aquatic exercise (at TT and BT) groups. The IFNγ profile is representative for 2 independent experiments with three mice per group. (C) Frequency (left) and number (right) of IFNγ+CD8+ T cells 3 wk after aquatic exercise. (D) dLN cells were isolated from housing and aquatic exercise (at BT and TT) groups of mice at 3 weeks. These cells were stimulated for 4 h with PMA and ionomycin and assessed for IFNγ expression by intracellular staining. The profile of IFNγ+CD8+ T cells in dLN (left), and a summary of frequencies (right). The IFNγ profile is representative for 2 independent experiments with three mice per group. Error bars represent mean and SEM. *p<0.05, **p<0.01, ***p<0.001. Figure 3. Enhancement of cytokine production by CD8+ T cells at TT. Tumor bearing mice had aquatic exercise (n=9 per group) and 3 mice were randomly sacrificed every wk after aquatic exercise. Splenocytes were isolated from housing and aquatic exercise (at TT and BT) groups of mice for 3 weeks and were stimulated for 4 h with PMA and ionomycin to… Immune Netw. 2019 Apr;19(2):e10. https://doi.org/10.4110/in.2019.19.e10