Supplement Figure 1 Untreated Thermal IMDP CPLL Untreated Thermal IMDP

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Supplement Figure 1 Untreated Thermal IMDP CPLL Untreated Thermal IMDP 75 100 135 63 48 35 25 17 11 MW (kDa) MW (kDa) 135 100 75 HSA (69 kDa) 63 48 IgG HC (55 kDa) 35 25 17 11 Supplement Figure 1

Number of peptide spectrum matches (#PSMs) Untreated Thermal IMDP CPLL Untreated Thermal IMDP CPLL Protein name Number of peptide spectrum matches (#PSMs) Untreated 1 2 3 Thermal IMDP CPLL Serum albumin 382 1135 1259 164 133 205 31 25 95 33 84 mean±SEM 925 ± 274 167 ± 21 19 ± 10 71 ± 19 Immunoglobulins 364 494 651 87 108 113 11 54 386 81 258 503 ± 83 103 ± 8 22 ± 17 242 ± 88 Supplementary figure 2

Untreated plasma Thermal treatment 18 8 Common Supplementary figure 3