Fig. 1 Engineered T cells: design of TCR versus CAR T cells.

Slides:

Advertisements

Similar presentations

The Principles of Engineering Immune Cells to Treat Cancer

Advertisements

Jacques F.A.P. Miller, Michel Sadelain Cancer Cell

Figure 1 Chimeric antigen receptor (CAR) structures

Antibody-modified T cells: CARs take the front seat for hematologic malignancies by Marcela V. Maus, Stephan A. Grupp, David L. Porter, and Carl H. June.

Will Engineered T Cells Expressing CD20 scFv Eradicate Melanoma?

CAR T cell therapy—principle and clinical trial overview

CAR T cell therapy—principle and clinical trial overview

Will Post-Transplantation Cell Therapies for Pediatric Patients Become Standard of Care? Arjan C. Lankester, Franco Locatelli, Peter Bader, Eva Rettinger,

Figure 1 CAR-T-cell design

Daniel Abate-Daga, Marco L Davila Molecular Therapy - Oncolytics

Miki Ando, Hiromitsu Nakauchi Experimental Hematology

Degradation of MSP samples in 37°C DPBS solution.

Basic design concept of human mimetic humanoid.

The Other Face of Chimeric Antigen Receptors

Three different types of transfer functions with a codomain of [0,1].

TPAD training protocol.

Research Techniques Made Simple: CAR T-Cell Therapy

Self-sensing of actuator position.

The Principles of Engineering Immune Cells to Treat Cancer

Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse Saad S. Kenderian, David L. Porter,

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Chimeric antigen receptor T-cell therapy for solid tumors

by Shannon L. Maude, David T. Teachey, David L. Porter, and Stephan A

Virus-specific T cell responses are detected in all MERS survivors.

Analysis of plasmablast responses in one naïve and three DENV-experienced donors. Analysis of plasmablast responses in one naïve and three DENV-experienced.

Fig. 5 Correlation of RNA expression and protein abundance.

The milliDelta: a millimeter-scale Delta robot.

Genetically modified TCRs for cancer immunotherapy.

Crystal structures of RSV G-antibody complexes.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. (A)

Fig. 3 Conditionally expressed CAR using Notch as a signal induction and response pathway system. Conditionally expressed CAR using Notch as a signal induction.

Evaluation of multidonor class Ig sequences obtained from H5N1 and H7N9 vaccinated donors. Evaluation of multidonor class Ig sequences obtained from H5N1.

Self-sensing of actuator position.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Degradation of MSP samples in 37°C DPBS solution.

Fig. 2 Average number of fake news shares (and 95% CIs) using the list of domains derived from (7). Average number of fake news shares (and 95% CIs) using.

Fig. 1 Engineered expression of PSMA variants on CD19 CAR T cells.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 5. Immunohistochemistry of the tumor microenvironment in GBM specimens before and after CART-EGFRvIII infusion. Immunohistochemistry of the tumor.

Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion.

Overview of DS-A*02:01 production and usage for affinity measurements.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 5 Conceptual diagram of the impact of acid deposition on calcium cycling and subsequent plant water use. Conceptual diagram of the impact of acid.

Fig. 1 Distribution of total and fake news shares.

Fig. 2 CAR T cell therapy is associated with cytokine release syndrome and neurotoxicity. CAR T cell therapy is associated with cytokine release syndrome.

AEGIS autonomous targeting process.

Fig. 1 Hypothesized models of intensity and polarization channel integration in crustaceans. Hypothesized models of intensity and polarization channel.

Fig. 2 ObR is cleaved and has reduced signaling capabilities after incubation with Mmp-2. ObR is cleaved and has reduced signaling capabilities after incubation.

CAR T cell immunotherapy for human cancer

Fig. 5. Vascularization of human liver seed grafts.

Fig. 3 Mmp-2−/− mice are protected from obesity and leptin resistance.

Fig. 1 Mmp-2 activity is increased in brains after HFD intake.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 1 Scheme for a multivariate linear combination in living cells.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 Map of δ18OVSMOW in groundwaters of the British Isles (left) and Strontium (87Sr/86Sr) biosphere map of Great Britain (right). Map of δ18OVSMOW.

Fig. 1 Multivalent proapoptotic DRAs can induce cell death in TRAIL-sensitive and TRAIL-resistant human CRC cell lines. Multivalent proapoptotic DRAs can.

Fig. 2 Increasing KLF17, CDH1, and LASS2 expression reduced malignant progression and promoted apoptosis of tumor cells. Increasing KLF17, CDH1, and LASS2.

Chimeric antigen receptor–modified T cells: CD19 and the road beyond

Breakdown of incorrect participant responses.

Fig. 3 Superiority of BAFF-R versus CD19-CAR T cells in a Burkitt lymphoma model is not due to greater tumor antigen density. Superiority of BAFF-R versus.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Robot-assisted intervention system.

Meningeal γδ T cell homeostasis is independent of inflammatory signals

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 5 Enhancers and super-enhancers identified in various brain cell populations. Enhancers and super-enhancers identified in various brain cell populations.

Fig. 5 CD19-tPSMA(N9del) CAR T cell numbers in mouse and human.

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Fig. 1 Engineered T cells: design of TCR versus CAR T cells. Engineered T cells: design of TCR versus CAR T cells. T cells can be redirected to have specificity for tumors by the introduction of (left) transgenic TCRs (T cell receptors) or (right) CAR (chimeric antigen receptor) proteins. CARs are fusion proteins composed of an extracellular portion that is usually derived from an antibody and intracellular signaling modules derived from T cell signaling proteins. First-generation CARs contain CD3ζ, whereas second-generation CARs possess a costimulatory endodomain (e.g., CD28 or 4-1BB) fused to CD3ζ. Third-generation CARs consist of two costimulatory domains linked to CD3ζ. scFv, single-chain variable fragment; VH, variable heavy chain; VL, variable light chain. Carl H. June et al. Science 2018;359:1361-1365 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works