Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest  Stephen M Langley, Paul J Chai, MD, James J Jaggers,

Slides:



Advertisements
Similar presentations
Aprotinin improves pulmonary function during reperfusion in an isolated lung model  Menen A Mathias, MD, Curtis G Tribble, MD, Jeffrey F Dietz, BS, Richard.
Advertisements

Effect of pressure management during hypothermic selective cerebral perfusion on cerebral hemodynamics and metabolism in pigs  Peter L. Haldenwang, MD,
Deep Hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children after infant cardiac surgery  Stephanie Fuller,
Prolonged White Matter Inflammation After Cardiopulmonary Bypass and Circulatory Arrest in a Juvenile Porcine Model  Ludmila Korotcova, MD, Sonali Kumar,
Regulation of Brain Cell Death and Survival After Cardiopulmonary Bypass  Tatiana Zaitseva, PhD, Steven Schultz, MD, Gregory Schears, MD, Peter Pastuszko,
Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs  Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich.
Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester  Takeshi Hiramatsu,
Regional low-flow perfusion provides somatic circulatory support during neonatal aortic arch surgery  Frank A Pigula, MD, Sanjiv K Gandhi, MD, Ralph D.
Single-Ventricle Physiology Reduces Cerebral Oxygen Delivery in a Piglet Model  Marco Ricci, MD, Pierluca Lombardi, MD, Alvaro Galindo, MD, Ernesto Coscarella,
Intermittent perfusion protects the brain during deep hypothermic circulatory arrest1  Stephen M Langley, Paul J Chai, MD, Sara E Miller, PhD, James R.
Circulatory Arrest and Low-Flow Cardiopulmonary Bypass Alter CREB Phosphorylation in Piglet Brain  Tatiana Zaitseva, PhD, Gregory Schears, MD, Steven.
S-100 after correction of congenital heart defects in neonates: is it a reliable marker for cerebral damage?  Michael A Erb, MD, Markus K Heinemann, MD,
Hyperoxia for management of acid-base status during deep hypothermia with circulatory arrest  Jeffrey M Pearl, MD, Donald W Thomas, Gary Grist, Jodie.
Newborn Aortic Arch Reconstruction With Descending Aortic Cannulation Improves Postoperative Renal Function  James M. Hammel, MD, Joseph J. Deptula, MPS,
Response of Brain Oxygenation and Metabolism to Deep Hypothermic Circulatory Arrest in Newborn Piglets: Comparison of pH-Stat and Alpha-Stat Strategies 
Optimal flow rate for antegrade cerebral perfusion
Severe ischemic early liver injury after cardiac surgery
Ji Zhang, MD, Robert D Furukawa, BSc, Stephen E Fremes, MD, Donald A
Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts  Jeffrey M Pearl, MD, David P Nelson, MD, PhD, Steven M Schwartz,
Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest  Elaine E Tseng, MD, Malcolm V Brock, MD, Christopher.
Opioid preconditioning: myocardial function and energy metabolism
Intraoperative myocardial protection: current trends and future perspectives  Gideon Cohen, MD, Michael A Borger, MD, Richard D Weisel, MD, Vivek Rao,
Cardiac Output Augmentation During Hypoxemia Improves Cerebral Metabolism After Hypothermic Cardiopulmonary Bypass  Jess M. Schultz, MD, Tara Karamlou,
Systemic steroid pretreatment improves cerebral protection after circulatory arrest  Dominique Shum-Tim, MD, Christo I Tchervenkov, MD, Al-Maleek Jamal,
Metabolic correlates of neurologic and behavioral injury after prolonged hypothermic circulatory arrest  Craig K. Mezrow, MSa, Alejandro Gandsas, MDa,
Improved Cerebral Recovery From Hypothermic Circulatory Arrest After Remote Ischemic Preconditioning  Fredrik S. Yannopoulos, MB, Tuomas Mäkelä, MB, Eija.
Masahiro Ono, MD, PhD, Charles Brown, MD, Jennifer K
Retrograde cerebral perfusion enhances cerebral protection during prolonged hypothermic circulatory arrest: a study in a chronic porcine model  Tatu Juvonen,
Optimal blood flow for cooled brain at 20°C
Ivan Ricardo Argueta-Morales, MD, Hamish M
Roland L Featherstone, PhD, David J Chambers, PhD, Frank J Kelly, PhD 
Traumatic tricuspid valve regurgitation and cerebral emboli
Cerebral autoregulation after hypothermic circulatory arrest in operations on the aortic arch  Eugenio Neri, MD, Carlo Sassi, MD, Lucio Barabesi, DrPh,
Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model  Akif Ündar, PhD, Takafumi Masai, MD, Shuang-Qiang Yang,
Effect of cerebral embolization on regional autoregulation during cardiopulmonary bypass in dogs  Hulya Sungurtekin, MD, Umar S Boston, MD, Thomas A Orszulak,
W. Brent Keeling, MD, David H. Tian, MD, PhD, Brad G
Modified Ultrafiltration Versus Conventional Ultrafiltration: A Randomized Prospective Study In Neonatal Piglets  C.William Daggett, MD, Andrew J. Lodge,
Blood gas management and degree of cooling: Effects on cerebral metabolism before and after circulatory arrest  Lynne A. Skaryak, MDa, Paul J. Chai, MDa,
Infant cardiopulmonary bypass: a procoagulant state
Hypothermic Low-Flow Cardiopulmonary Bypass Impairs Pulmonary and Right Ventricular Function More Than Circulatory Arrest  Jess M. Schultz, MD, Tara Karamlou,
Temperature Dependence of Cerebral Blood Flow for Isolated Regions of the Brain During Selective Cerebral Perfusion in Pigs  Justus T. Strauch, MD, Peter.
Straight Deep Hypothermic Arrest: Experience in 394 Patients Supports Its Effectiveness as a Sole Means of Brain Preservation  Arjet Gega, MD, John A.
High Flow Rates During Modified Ultrafiltration Decrease Cerebral Blood Flow Velocity and Venous Oxygen Saturation in Infants  Rosendo A. Rodriguez, MD,
Near-infrared monitoring of myocardial oxygenation during ischemic preconditioning  Michio Kawasuji, MD, Masahiro Ikeda, MD, Naoki Sakakibara, MD, Susumu.
Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest 
Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs  Marc L. Schermerhorn,
Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart  Zhi-Li Cao, MD, Yukio Okazaki, MD, Kozo Naito, MD, Tetsuya Ueno,
Jorge D. Salazar, MD, Ryan D
Delayed impairment of cerebral oxygenation after deep hypothermic circulatory arrest in children  Eero J Pesonen, MD, Kaija I Peltola, MD, Reijo E Korpela,
Deep hypothermic circulatory arrest during the arterial switch operation is associated with reduction in cerebral oxygen extraction but no increase in.
Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia  James D McCully, PhD, Masahisa Uematsu,
Three-graft technique for ascending aorta and total aortic arch replacement  Gen-ya Yaginuma, MD, Yoshiyuki Iijima, MD, Kazuo Abe, MD, Yoshiyuki Okada,
Lynne A. Skaryak, MDa (by invitation), Paul M
Heat shock improves recovery and provides protection against global ischemia after hypothermic storage  Ashok Gowda, MS, Chunjie Yang, MD, Gregory K Asimakis,
Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest  Rosendo A. Rodriguez, MD, PhDa (by.
2,3-Butanedione monoxime cardioplegia: advantages over hyperkalemia in blood- perfused isolated hearts  A.Mark Jayawant, MD, Edward R. Stephenson, MD,
Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.
Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures 
“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:
Critical cerebral perfusion pressure during tepid heart operations in dogs  Walter Plöchl, MD, David J. Cook, MD, Thomas A. Orszulak, MD, Richard C. Daly,
Aprotinin in deep hypothermic circulatory arrest
David J Chambers, PhD, David J Hearse, DSc 
Prospective randomized neurocognitive and S-100 study of hypothermic circulatory arrest, retrograde brain perfusion, and antegrade brain perfusion for.
The Brain Uses Mostly Dissolved Oxygen During Profoundly Hypothermic Cardiopulmonary Bypass  Franklin Dexter, MD, PhD, Frank H Kern, MD, Bradley J Hindman,
Perfusing the Cold Brain: Optimal Neuroprotection for Aortic Surgery
Carbon dioxide management and the cerebral response to hemodilution during hypothermic cardiopulmonary bypass in dogs  David J Cook, MD, Umar S Boston,
Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury  Christine S Rinder, MD, Manuel Fontes, MD,
Effect of hypothermia on cerebral blood flow and metabolism in the pig
Marek P. Ehrlich, MDa, Christian Hagl, MDa, Jock N
Hemostasis Alterations in Patients With Acute Aortic Dissection
Presentation transcript:

Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest  Stephen M Langley, Paul J Chai, MD, James J Jaggers, MD, Ross M Ungerleider, MD  The Annals of Thoracic Surgery  Volume 68, Issue 5, Pages 1578-1584 (November 1999) DOI: 10.1016/S0003-4975(99)00998-4

Fig 1 Global and regional cerebral blood flow (CBF) at 1 hour of reperfusion after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C in control and ginkgolide B groups. Data are expressed as percentage of baseline CBF before DHCA (mean ± standard error of the mean) (HEMI = cerebral hemispheres; CBLM = cerebellum; BG = basal ganglia; BS = brain stem; ∗significantly greater percentage recovery than control group, unpaired t test p < 0.05; †no significant difference from pre-DHCA value within group, paired t test p > 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)

Fig 2 Global and regional cerebral metabolic rate of oxygen (CMRO2) at 1 hour of reperfusion after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C in control and ginkgolide B groups. Data are expressed as percentage of baseline CMRO2 before DHCA (mean ± standard error of the mean) (HEMI = cerebral hemispheres; CBLM = cerebellum; BG = basal ganglia; BS = brain stem; ∗significantly greater percentage recovery than control group, unpaired t test p < 0.05; †no significant difference from pre-DHCA value within group, paired t test p > 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)

Fig 3 Renal blood flow in control and ginkgolide B groups at initial baseline (Pre-DHCA) and at 1 hour of reperfusion (Post-DHCA) after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C. Data are expressed as mean ± standard error of the mean. (CDO2 = cerebral oxygen delivery; CEO2 = cerebral oxygen extraction; CMRO2 = cerebral metabolic rate of oxygen; ∗significant difference from pre-DHCA value within group, paired t test p < 0.05; †significant difference from control value post-DHCA, unpaired t test p < 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)

Fig 4 Cerebral oxygen handling in the gingkolide B group (n = 7) at initial baseline (Pre-DHCA) and at 1 hour of reperfusion (Post-DHCA) after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C. Data are expressed as mean ± standard error of the mean. (CDO2 = cerebral oxygen delivery; CEO2 = cerebral oxygen extraction; CMRO2 = cerebral metabolic rate of oxygen; ∗significant difference from pre-DHCA value within group, paired t test p < 0.05; †significant difference from control value post-DHCA, unpaired t test p < 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)