Platelet-activating factor receptor antagonism improves cerebral recovery after circulatory arrest Stephen M Langley, Paul J Chai, MD, James J Jaggers, MD, Ross M Ungerleider, MD The Annals of Thoracic Surgery Volume 68, Issue 5, Pages 1578-1584 (November 1999) DOI: 10.1016/S0003-4975(99)00998-4
Fig 1 Global and regional cerebral blood flow (CBF) at 1 hour of reperfusion after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C in control and ginkgolide B groups. Data are expressed as percentage of baseline CBF before DHCA (mean ± standard error of the mean) (HEMI = cerebral hemispheres; CBLM = cerebellum; BG = basal ganglia; BS = brain stem; ∗significantly greater percentage recovery than control group, unpaired t test p < 0.05; †no significant difference from pre-DHCA value within group, paired t test p > 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)
Fig 2 Global and regional cerebral metabolic rate of oxygen (CMRO2) at 1 hour of reperfusion after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C in control and ginkgolide B groups. Data are expressed as percentage of baseline CMRO2 before DHCA (mean ± standard error of the mean) (HEMI = cerebral hemispheres; CBLM = cerebellum; BG = basal ganglia; BS = brain stem; ∗significantly greater percentage recovery than control group, unpaired t test p < 0.05; †no significant difference from pre-DHCA value within group, paired t test p > 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)
Fig 3 Renal blood flow in control and ginkgolide B groups at initial baseline (Pre-DHCA) and at 1 hour of reperfusion (Post-DHCA) after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C. Data are expressed as mean ± standard error of the mean. (CDO2 = cerebral oxygen delivery; CEO2 = cerebral oxygen extraction; CMRO2 = cerebral metabolic rate of oxygen; ∗significant difference from pre-DHCA value within group, paired t test p < 0.05; †significant difference from control value post-DHCA, unpaired t test p < 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)
Fig 4 Cerebral oxygen handling in the gingkolide B group (n = 7) at initial baseline (Pre-DHCA) and at 1 hour of reperfusion (Post-DHCA) after 60 minutes of deep hypothermic circulatory arrest (DHCA) at 18°C. Data are expressed as mean ± standard error of the mean. (CDO2 = cerebral oxygen delivery; CEO2 = cerebral oxygen extraction; CMRO2 = cerebral metabolic rate of oxygen; ∗significant difference from pre-DHCA value within group, paired t test p < 0.05; †significant difference from control value post-DHCA, unpaired t test p < 0.05.) The Annals of Thoracic Surgery 1999 68, 1578-1584DOI: (10.1016/S0003-4975(99)00998-4)