Volume 60, Issue 6, Pages (December 2001)

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Volume 60, Issue 6, Pages 2318-2323 (December 2001) Acute administration of L-arginine does not improve arterial endothelial function in chronic renal failure Jenny M. Cross, Ann E. Donald, Rajesh Kharbanda, John E. Deanfield, Robin G. Woolfson, Raymond J. MacAllister Kidney International Volume 60, Issue 6, Pages 2318-2323 (December 2001) DOI: 10.1046/j.1523-1755.2001.00059.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Experimental protocol 3. Effect of local intrarterial infusion of L-arginine on endothelial function of conduit and resistance arteries in patients with predialysis renal failure. Kidney International 2001 60, 2318-2323DOI: (10.1046/j.1523-1755.2001.00059.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Competitive inhibition of nitric oxide synthase (NOS) by L-arginine analogs is reversible in healthy volunteers. Flow-mediated dilation (FMD) was reduced by NGmonomethyl-L-arginine (L-NMMA; P < 0.01 by ANOVA) and restored by intravenous infusion of L-arginine (P >0.05 by ANOVA). Kidney International 2001 60, 2318-2323DOI: (10.1046/j.1523-1755.2001.00059.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Effect of intravenous L-arginine in dialysis-dependent renal failure. (A) The velocity time integral [VTI(m)] was recorded for 90 seconds after cuff release before (○) and after (•) intravenous L-arginine. The flow stimulus was not affected by L-arginine infusion (N = 18; ANOVA, P = 0.1). (B) Intravenous L-arginine did not improve brachial flow-mediated dilatation (FMD) or dilatation to glyceryltrinitrate (GTN; N = 18) in dialysis dependent subjects. (C) Profile of FMD for the 4 minute period after cuff release is shown before (○) and after (•) L-arginine infusion. L-arginine had no effect on dilation. Kidney International 2001 60, 2318-2323DOI: (10.1046/j.1523-1755.2001.00059.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Effect of intrabrachial infusion of L-arginine on vascular function in subjects with pre-dialysis renal failure. (A) Intrabrachial L-arginine did not improve radial flow-mediated dilation (N = 8; P = 0.8). (B) Intrabrachial L-arginine did not improve resistance vessel response to the endothelium-dependent dilator acetylcholine (N = 8; P = 0.9). Symbols are: (□) before infusion; (▪) after infusion of L-arginine. Kidney International 2001 60, 2318-2323DOI: (10.1046/j.1523-1755.2001.00059.x) Copyright © 2001 International Society of Nephrology Terms and Conditions