PD-L1 expression by DC subsets from lesional CTCL and healthy skin.

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PD-L1 expression by DC subsets from lesional CTCL and healthy skin. PD-L1 expression by DC subsets from lesional CTCL and healthy skin. Flow-cytometry histograms of PD-L1 expression from 3 healthy skin (top row) and 3 CTCL patients (bottom row). In each panel, the solid histogram represents unstained controls, and the dotted lines each represent 1 of 3 lesional CTCL or healthy skin samples. The gating parameters were as follows: epidermal LCs (CD1a+, CD14neg, HLA-DRbright), dermal CD1a+ DCs (CD1a+, CD14neg, HLA-DRbright, CD11b+, CD11c+), and dermal CD14+ DCs (CD1aneg, CD14+, HLA-DRbright, CD11b+, CD11c+). The Mann–Whitney U test was used to calculate the P values. Data are from one independent experiment. Christiane Querfeld et al. Cancer Immunol Res 2018;6:900-909 ©2018 by American Association for Cancer Research