D. Obal, B. Preckel, H. Scharbatke, J. Müllenheim, F. Höterkes, V

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Presentation transcript:

One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo D. Obal, B. Preckel, H. Scharbatke, J. Müllenheim, F. Höterkes, V. Thämer, W. Schlack British Journal of Anaesthesia Volume 87, Issue 6, Pages 905-911 (December 2001) DOI: 10.1093/bja/87.6.905 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Registration showing selected times from one experiment where 1 MAC sevoflurane was given during initial reperfusion. LVP=left ventricular pressure, dP/dt=rate of change of LVP, AOP=aortic pressure, Flow A.pulm.=pulmonary artery flow, ECG=electrocardiogram. British Journal of Anaesthesia 2001 87, 905-911DOI: (10.1093/bja/87.6.905) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Line plot showing the time course of heart rate (HR), left ventricular peak systolic pressure (LVPSP) and systemic vascular resistance (SVR) during the experiments (data are mean (95% confidence interval), *P<0.05 vs baseline). LVPSP and SVR decreased in a concentration-dependent manner during initial reperfusion, but no differences between the treatment groups were observed at the end of the experiments. Baseline values were: HR (beats min−1): controls, 441 (413–467); 0.75 MAC, 431 (407–456); 1 MAC, 443 (423–462); 1.5 MAC, 444 (426–462); 2 MAC, 441 (412–470). LVPSP (mm Hg): controls, 125 (112–138); 0.75 MAC, 130 (122–137); 1 MAC, 132 (120–144); 1.5 MAC, 135 (126–144); 2 MAC, 129 (116–142). SVR (mm Hg ml−1 min): controls, 3.2 (2.6–3.8); 0.75 MAC, 3.7 (3.2–4.2); 1 MAC, 3.5 (3.0–4.1); 1.5 MAC, 3.3 (2.8–3.7); 2 MAC, 3.5 (2.7–4.3). British Journal of Anaesthesia 2001 87, 905-911DOI: (10.1093/bja/87.6.905) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Infarct size expressed as per cent of the area at risk. Open symbols represent single data points, filled symbols are mean and 95% confidence interval; *P<0.05. British Journal of Anaesthesia 2001 87, 905-911DOI: (10.1093/bja/87.6.905) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions