Increased Type 1 Immune Response in the Bone Marrow Immune Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell.

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Increased Type 1 Immune Response in the Bone Marrow Immune Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation Yu-Tong Wang, Yuan Kong, Yang Song, Wei Han, Yuan-Yuan Zhang, Xiao-Hui Zhang, Ying-Jun Chang, Zheng-Fan Jiang, Xiao-Jun Huang Biology of Blood and Marrow Transplantation Volume 22, Issue 8, Pages 1376-1382 (August 2016) DOI: 10.1016/j.bbmt.2016.04.016 Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Immunophenotypic analysis of Tc1, Tc2, Th1, and Th2 cells. The lymphocytic population was initially defined using a forward (FSC) and side scatter (SSC) gate (A). CD4+ T cells and CD8+ T cells were then gated based on the CD8 antigen (B). Representative fluorescence-activated cell sorting analysis of CD8−IFN-γ+ Th1 cells and CD8+IFN-γ+ Tc1 cells from a PGF patient (C), a GGF patient (D), an HD, and (E) CD8−IL-4+ Th2 cells and CD8+L-4+ Tc2 cells from a PGF patient (F), a GGF patient (G), and an HD (H) are provided. Biology of Blood and Marrow Transplantation 2016 22, 1376-1382DOI: (10.1016/j.bbmt.2016.04.016) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 IFN-γ (A) and IL-4 (B) levels in BM plasma, as measured by cytometric beads assay. The PGF patients exhibited significantly elevated plasma IFN-γ levels compared with HD and decreased plasma IL-4 levels compared with GGF patients and HD. Biology of Blood and Marrow Transplantation 2016 22, 1376-1382DOI: (10.1016/j.bbmt.2016.04.016) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 The percentages of Th1 (A) and Th2 (B) cells among CD4+ T cells and Tc1 (D) and Tc2 (E) cells among CD8+ T cells. Th1/Th2 (C) and Tc1/Tc2 (F) ratios are indicated. Statistical analyses were performed using the Mann-Whitney U test. Biology of Blood and Marrow Transplantation 2016 22, 1376-1382DOI: (10.1016/j.bbmt.2016.04.016) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions