Bistra Iordanova, Matthew C. Murphy, William E. Klunk, Alberto L

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IN VIVO NADH FLUORESCENCE IMAGING OF DOUBLE TRANSGENIC AD MICE REVEALS CHRONIC TISSUE HYPOXIA  Bistra Iordanova, Matthew C. Murphy, William E. Klunk, Alberto L. Vazquez  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 12, Issue 7, Pages P30-P31 (July 2016) DOI: 10.1016/j.jalz.2016.06.040 Copyright © 2016 Terms and Conditions

Figure 1 In vivo NADH fluorescence imaging of AD mice reveals chronic tissue hypoxia and cellular metabolic shift. A) Characteristic NADH pattern after reduction of oxygen supply. Arrowheads pointing to a vein; asterisks at arteries. B) Two-photon imaging under the same conditions shows numerous cells with increased signal (green). C) A subset of those cells stain positive for the astrocyte marker SR101 (red). Arrowheads at cells double positive for NADH and SR101. D) Cortex also shows heavy CAA (blue) and tissue plaques (blue, asterisks). Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P30-P31DOI: (10.1016/j.jalz.2016.06.040) Copyright © 2016 Terms and Conditions

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