Niamh E. Kieran, Paola Maderna, Catherine Godson Kidney International

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Presentation transcript:

Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease Niamh E. Kieran, Paola Maderna, Catherine Godson Kidney International Volume 65, Issue 4, Pages 1145-1154 (April 2004) DOI: 10.1111/j.1523-1755.2004.00487.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Transcellular generation of lipoxin A4 (LXA4) and 15-epi-lipoxin A4. P-selectin–mediated endothelial-polymorphonuclear neutrophil (PMN) interaction facilitates LXA4 biosynthesis. In a cytokine primed milieu aspirin acetylation of endothelial cyclooxygenase (COX-2) facilitates the transcellular generation of 15-epi-LXA4. Abbreviations are: LO, lipoxygenase; AA, arachidonic acid; LX: lipoxin, HETE: hydroxyeicosatetraneoic acid. (From McMahon B, Mitchell S, Brady HR, Godson C: Lipoxins: Revelations on resolution. Trends Pharmacol Sci 22:391–395, 2001, with permission.) Kidney International 2004 65, 1145-1154DOI: (10.1111/j.1523-1755.2004.00487.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Potential cellular targets of lipoxin in the kidney. Lipoxins demonstrate anti-inflammatory and proresolution actions within the kidney, modulating responses in numerous cell types, including endothelial cells, mesangial cells, polymorphonuclear neutrophils (PMNs), monocytes, and macrophages as described in the text. Kidney International 2004 65, 1145-1154DOI: (10.1111/j.1523-1755.2004.00487.x) Copyright © 2004 International Society of Nephrology Terms and Conditions