Volume 65, Issue 6, Pages (March 2017)

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Volume 65, Issue 6, Pages 957-958 (March 2017) Prokaryotic Argonaute Uses an All-in-One Mechanism to Provide Host Defense Dipali G. Sashital Molecular Cell Volume 65, Issue 6, Pages 957-958 (March 2017) DOI: 10.1016/j.molcel.2017.03.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Model for All-in-One pAgo Mechanism Unguided pAgo preferentially chops foreign DNA, creating short dsDNA fragments. These fragments are selectively loaded based on the presence of a deoxyguanosine residue opposite the 5′ end of the guide strand. Upon binding to a chopping product, guided pAgo cleaves foreign DNA in regions specified by the guide strand. Molecular Cell 2017 65, 957-958DOI: (10.1016/j.molcel.2017.03.002) Copyright © 2017 Elsevier Inc. Terms and Conditions