Volume 22, Issue 1, Pages 5-7 (January 2018)

Slides:

Advertisements

Similar presentations

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Healthy clocks, healthy body, healthy mind Akhilesh B. Reddy, John S. O’Neill Trends in Cell Biology Volume 20, Issue 1, Pages (January 2010) DOI:

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey

T-ALL: Home Is where the CXCL12 Is

Dysfunctional Niches as a Root of Hematopoietic Malignancy

Martin Wahlestedt, David Bryder Cell Stem Cell

Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey

Scott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté

Volume 1, Issue 1, Pages (June 2007)

Cell Cycle Rules Pluripotency

Adipocytes at the Core of Bone Function

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

A Path to Insulin Independence: “The End of the Beginning”

Volume 9, Issue 2, Pages (August 2011)

Christopher Hine, James R. Mitchell Cell Stem Cell

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Christopher Hine, James R. Mitchell Cell Stem Cell

MDS Is a Stem Cell Disorder After All

Directing Stem Cell Homing

Volume 14, Issue 2, Pages (February 2014)

Maintaining Hematopoietic Stem Cells in the Vascular Niche

Stressed-Out HSCs Turn Up p38α and Purine to Proliferate

Regulating Cancer Stem Cells the miR Way

Wing Y. Chang, William L. Stanford Cell Stem Cell

A New Image of the Hematopoietic Stem Cell Vascular Niche

Volume 154, Issue 1, Pages (July 2013)

Stem Cell Therapies in Clinical Trials: Progress and Challenges

Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

HSPCs Get Their Motors Running for Asymmetric Fate Choice

Dysfunctional Niches as a Root of Hematopoietic Malignancy

Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays

AMPK Keeps Tumor Cells from Starving to Death

Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs

Putting Two Heads Together to Build a Better Brain

Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,

Volume 18, Issue 2, Pages (February 2016)

Ulrike Harjes, Catherine Verfaillie, Peter Carmeliet

Volume 152, Issue 1, (January 2013)

Cycling toward Elimination of Leukemic Stem Cells

Meddling with METTLs in Normal and Leukemia Stem Cells

Powering Reprogramming with Vitamin C

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Disrupting the Stem Cell Niche: Good Seeds in Bad Soil

Waddington’s Valleys and Captain Cook’s Islands

Maintaining Hematopoietic Stem Cells in the Vascular Niche

Transition of Endothelium to Cartilage and Bone

Volume 22, Issue 4, Pages (April 2018)

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Chapter 29 - Stem Cells and Generation of New Cells in the

On Bone-Forming Cells and Blood Vessels in Bone Development

Mary Eapen Biology of Blood and Marrow Transplantation

Volume 148, Issue 1, (January 2012)

Mark C. Horowitz, Steven M. Tommasini Cell Stem Cell

Presentation transcript:

Volume 22, Issue 1, Pages 5-7 (January 2018) Chewing through Roots: How Leukemia Invades and Disrupts the Bone Marrow Microenvironment Owen J. Tamplin Cell Stem Cell Volume 22, Issue 1, Pages 5-7 (January 2018) DOI: 10.1016/j.stem.2017.12.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 AML Progression Disrupts Specific Regions of the Bone Marrow Microenvironment In healthy BM (1), the trabecular metaphysis is enriched with endosteal vessels, while the central marrow of the diaphysis is mostly sinusoidal vessels. With an intermediate level of AML cell infiltration (2), endosteal vessels are reduced. With more advanced AML infiltration (3), osteoblasts are also lost. Sinusoidal vessels are not reduced, but they narrow, move further from bone, and extend vascular sprouts. Cell Stem Cell 2018 22, 5-7DOI: (10.1016/j.stem.2017.12.014) Copyright © 2017 Elsevier Inc. Terms and Conditions