The acquisition of tolerance toward cow's milk through probiotic supplementation: A randomized, controlled trial Jeroen Hol, MD, Eduard H.G. van Leer,

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Presentation transcript:

The acquisition of tolerance toward cow's milk through probiotic supplementation: A randomized, controlled trial Jeroen Hol, MD, Eduard H.G. van Leer, MD, PhD, Beatrix E.E. Elink Schuurman, MScN, Lilian F. de Ruiter, Janneke N. Samsom, PhD, Wim Hop, MD, PhD, Herman J. Neijens, MD, PhD, Johan C. de Jongste, MD, PhD, Edward E.S. Nieuwenhuis, MD, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 6, Pages 1448-1454 (June 2008) DOI: 10.1016/j.jaci.2008.03.018 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Design of the CAMEL study. Journal of Allergy and Clinical Immunology 2008 121, 1448-1454DOI: (10.1016/j.jaci.2008.03.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Flow chart of the study population. FU, Follow-up; IC, informed consent. Journal of Allergy and Clinical Immunology 2008 121, 1448-1454DOI: (10.1016/j.jaci.2008.03.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 No additional effects of probiotics on clinical severity of AEDS is shown. Mean SCORAD scores (± SEM) at randomization and 6 and 12 months of study formula are shown. Solid squares, placebo group (n = 54); open circles, probiotic group (n = 51). SCORAD scores significantly improved from baseline in the probiotics group at 6 and 12 months and in the placebo group at only 6 months. Journal of Allergy and Clinical Immunology 2008 121, 1448-1454DOI: (10.1016/j.jaci.2008.03.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 CD3+ percentage in lymphocyte gate at 0 and 12 months categorized into intervention and outcome at 12 months. CD3+ change from baseline for infants with persistent CMA compared with that seen in tolerant infants was significantly different, being 4.7% higher in the persistent CMA group (∗P = .032, adjusted for baseline). This difference was independent of the probiotic intervention. Data are expressed as means (95% CIs). Journal of Allergy and Clinical Immunology 2008 121, 1448-1454DOI: (10.1016/j.jaci.2008.03.018) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions