Understanding How Hepatitis C Virus Builds Its Unctuous Home

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Presentation transcript:

Understanding How Hepatitis C Virus Builds Its Unctuous Home Brett D. Lindenbach Cell Host & Microbe Volume 9, Issue 1, Pages 1-2 (January 2011) DOI: 10.1016/j.chom.2011.01.002 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 PI4KIIIα Is Needed for HCV Replication Complex Assembly (A and B) HCV RNA replication is thought to take place within invaginations of an ER-derived membrane. The viral NS3-4A, NS4B, NS5A, and NS5B proteins are all essential for this process (A). NS5A binds and activates PI4KIIIα, leading to the local production of PI4P (B). One possibility is that PI4P then recruits viral or cellular factors that are essential for forming the replication compartment. Cell Host & Microbe 2011 9, 1-2DOI: (10.1016/j.chom.2011.01.002) Copyright © 2011 Elsevier Inc. Terms and Conditions