Mathematically engineered stromal cell–derived factor-1α stem cell cytokine analog enhances mechanical properties of infarcted myocardium John W. MacArthur,

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Presentation transcript:

Mathematically engineered stromal cell–derived factor-1α stem cell cytokine analog enhances mechanical properties of infarcted myocardium John W. MacArthur, MD, Alen Trubelja, BS, Yasuhiro Shudo, MD, Philip Hsiao, BA, Alexander S. Fairman, BA, Elaine Yang, MS, William Hiesinger, MD, Joseph J. Sarver, PhD, Pavan Atluri, MD, Y. Joseph Woo, MD The Journal of Thoracic and Cardiovascular Surgery Volume 145, Issue 1, Pages 278-284 (January 2013) DOI: 10.1016/j.jtcvs.2012.09.080 Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Ventricles were opened along the posterior free wall, adjacent to the septum and longitudinally sectioned (white hash marks) for tensile testing. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Ventricular strip with custom-made polytetrafluoroethylene pledgets reinforcing the edges. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Image of ventricular strip inside the temperature-regulated bath, connected to the Instron microtester (Instron, Norwood, Mass). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Representative images of infarct sizes. A, Sham operated group, (B) saline control group, and (C) engineered stromal cell–derived factor-1α analog experimental (ESA) group. Although overall scar area was similar between saline control and ESA groups, it appears that the quality of the scar was different. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Representative cross-sectional images of hematoxylin and eosin–stained section of ventricles from (A) sham group, (B) saline control, and (C) ESA group. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 6 Representative cross-sectional images of Masson’s trichrome–stained sections of ventricles from (A) sham group, (B) saline control group, and (C) ESA group. On analysis under 20× objective, infarcts in the ESA group had significantly less collagen than in the saline control group (ESA group, 30.8% ± 5.7%; saline control, 38.6%; P = .01). The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Figure 7 A, Ejection fraction and (B) tensile modulus of the different groups. ∗P < .05. ESA, Engineered stromal cell–derived factor-1α analog; LAD, left anterior descending (artery); MI, myocardial infarction; Pre-op, preoperative. The Journal of Thoracic and Cardiovascular Surgery 2013 145, 278-284DOI: (10.1016/j.jtcvs.2012.09.080) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions