Fig. 5 Active-state hallmarks of US28 bound to CX3CL1.

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Fig. 5 Active-state hallmarks of US28 bound to CX3CL1. Active-state hallmarks of US28 bound to CX3CL1. (A) Comparison between the TM6 conformations of US28 (orange) and CCR5 (green; PDB ID: 4MBS). (B) The NPXXY motif of US28 (orange) forms side-chain contacts resembling the active-state conformation of β2AR (light blue; PDB ID: 3SN6). (C) The DRY motif of US28 (orange) forms side-chain contacts resembling the active-state conformation of β2AR (light blue). John S. Burg et al. Science 2015;347:1113-1117 Copyright © 2015, American Association for the Advancement of Science