Andrew D Cochrane, Shobhna Pathik, Joseph J Smolich, Robert A

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Depressed Function in Remote Myocardium After Myocardial Infarction: Influence of Orotic Acid Andrew D Cochrane, Shobhna Pathik, Joseph J Smolich, Robert A.J Conyers, Franklin L Rosenfeldt The Annals of Thoracic Surgery Volume 62, Issue 6, Pages 1765-1772 (December 1996) DOI: 10.1016/S0003-4975(96)00673-X

Fig. 1 The experimental protocol. (LAD = left anterior descending coronary artery; MI = myocardial infarct.) The Annals of Thoracic Surgery 1996 62, 1765-1772DOI: (10.1016/S0003-4975(96)00673-X)

Fig. 2 Cross-sectional view of the left ventricle (LV) at mid-papillary level. (A) Area of infarction on the anatomic section. (B) Computer-derived output of the end-diastolic and end-systolic contours, and the 36 radiants used to measure function. The radiants used for the infarct, remote zone, and border zone are indicated. (C) Graphic representation of the radial shortening. (LV = left ventricle.) The Annals of Thoracic Surgery 1996 62, 1765-1772DOI: (10.1016/S0003-4975(96)00673-X)

Fig. 3 Fractional radial shortening in the infarct, border zone, and remote zones before infarction (Pre-MI) and on day 1 and day 3 after infarction. There was no difference between the control and treated groups. Significantly different from before infarction: *p <0.05; **p <0.01; ***p <0.001. (OA = orotic acid.) The Annals of Thoracic Surgery 1996 62, 1765-1772DOI: (10.1016/S0003-4975(96)00673-X)

Fig. 4 Effect of β-blockade on fractional radial shortening in the infarct, border zone, and remote myocardium for the control animals (n = 12), before infarction (Pre-MI) and on day 3 after infarction. Significant difference from pre-β-blockade value: *p <0.05; **p <0.01; ***p <0.001. The Annals of Thoracic Surgery 1996 62, 1765-1772DOI: (10.1016/S0003-4975(96)00673-X)

Fig. 5 Fractional radial shortening in the infarct, border zone, and remote myocardium in 6 dogs (3 treated and 3 untreated) studied for 9 days after infarction. The Annals of Thoracic Surgery 1996 62, 1765-1772DOI: (10.1016/S0003-4975(96)00673-X)

Fig. 6 Left ventricular stroke work indexed for body weight (LVSWI), plotted against left atrial pressure for the orotic acid-treated (MI + OA, n = 8), untreated (MI, n = 8), and noninfarcted (Normal, n = 6) groups with β-blockade. Maximum stroke work in infarcted groups is significantly less than in noninfarcted dogs (p <0.001). There was no difference between treated and control groups (p = 0.25). The Annals of Thoracic Surgery 1996 62, 1765-1772DOI: (10.1016/S0003-4975(96)00673-X)