Fig. 6. Prolonged miR302-367 overexpression in the adult heart reduces fibrotic scar size but compromises cardiac function after MI. Prolonged miR302-367.

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Fig. 6. Prolonged miR302-367 overexpression in the adult heart reduces fibrotic scar size but compromises cardiac function after MI. Prolonged miR302-367 overexpression in the adult heart reduces fibrotic scar size but compromises cardiac function after MI. (A) Study design of miR302-367 overexpression by tamoxifen intraperitoneal injection after MI by ligation of the left anterior descending (LAD) coronary artery. (B) Masson’s trichrome–stained heart sections from the site of ligation toward the apex of control and Myh6mercremer:R26R-miR302-367Tg/+ mice at 21 days after MI. Serial sections were cut at 500-μm intervals from the site of the ligature toward the apex. One representative Myh6mercremer and two Myh6mercremer:R26R-miR302-367Tg/+ hearts are shown (n = 6 per group). (C) Quantification of the fibrotic regions in heart sections in (B). (D) Immunostaining and quantification of PH3+/α-actinin+ cells in Myh6mercremer and Myh6mercremer:R26R-miR302-367Tg/+ hearts at 21 days after MI. (E) Cardiac function in mice subjected to LAD ligation, evaluated by echocardiography (n = 7 per group). EF, ejection fraction; FS, fractional shortening; EDV, end-diastolic volume; ESV, end-systolic volume. Data are means ± SEM (n = 6 to 7). (C and D) P values determined with Student’s t test. (E) *P < 0.05 versus sham, by one-way analysis of variance (ANOVA). Ying Tian et al., Sci Transl Med 2015;7:279ra38 Copyright © 2015, American Association for the Advancement of Science