Modified Scott test Chen-Kao test

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Modified Scott test Chen-Kao test Cocaine HCl:diltiazem HCl Cocaine HCl:myo-inositol Cocaine HCl:starch Cocaine HCl 25:75 50:50 75:25 90:10 25:75 50:50 75:25 90:10 25:75 50:50 75:25 90:10 Step 1 Step 2 Filtration Step 3 Chen-Kao test Cocaine HCl:diltiazem HCl Cocaine HCl:myo-inositol Cocaine HCl:starch Cocaine HCl 25:75 50:50 75:25 90:10 25:75 50:50 75:25 90:10 25:75 50:50 75:25 90:10 time 0 Scott 1, cocaine –diltiazem (0031), cocaine –inositol (0034), cocaine –starch (0036), Scott 2, cocaine –diltiazem (0041), cocaine –inositol (0044), cocaine –starch(0046), Scott 3, cocaine –diltiazem (0065), cocaine –inositol (0066), cocaine –starch (0069), Chen-Kao time immediate, cocaine –diltiazem (0076), cocaine –inositol (0084), cocaine –starch (0090), 1 min cocaine –diltiazem (0077), cocaine –inositol (0085), cocaine –starch (0091), 2 min cocaine –diltiazem (0078), cocaine –inositol (0086), cocaine –starch (0092), 5 min cocaine –diltiazem (0081), cocaine –inositol (0089), cocaine –starch (0095), 1 min Time after addition of the solution 3 2 min 5 min Fig. S4