Schematic of experimental parameters comparing FFPE DNA repair methods to FF DNA. DNA (500 ng) from FF tissue was processed according to Illumina Human.

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DNA Methylation mapping

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Flow diagram of the literature search and selection process in the PubMed and Scopus databases. Flow diagram of the literature search and selection process.

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IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

miRNA expression patterns in stools from healthy subjects.

ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve.

A, genomic copy number profiles of chromosome 8 with array CGH in SUM-44, -52, and A, genomic copy number profiles of chromosome 8 with array CGH.

HPLC analysis of the glucosinolate composition of the broccoli sprouts (A) and placebo (C) beverages prepared from the first and fourth aqueous extracts.

Density Density ß values ß values

The human GPR109A promoter is methylated and GPR109A expression is silenced in human colon carcinoma cells. The human GPR109A promoter is methylated and.

Principal component analysis of adipose tissue fatty acids.

NICD1 immunohistochemical staining in normal and tumor tissue.

Clinically significant precounseling cancer distress modifies counseling method's effect on testing uptake. *, statistically significant difference observed.

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Gene expression of epigenetic modulators, HDAC1 and Dnmt1, and the histone acetylation modification patterns by the prenatal/maternal BSp dietary treatment.

Correlation of DNA methylation analysis between Illumina EPIC methylation array and tNGBS platforms. Correlation of DNA methylation analysis between Illumina.

The TSDR of ATL cells exhibits Treg-like hypomethylated status or CD4+ conventional T cell–like methylated status. The TSDR of ATL cells exhibits Treg-like.

BRCA1 promoter methylation detected in the peripheral blood and corresponding tumor. BRCA1 promoter methylation detected in the peripheral blood and corresponding.

Methylation status of IGFBPL1 in human breast cancer.

Histopathologic characteristics in HL-mice and HL-HPS-mice.

Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC region. Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC

Meta-analysis of five prospective studies examining the associations between urinary melatonin secretion and breast cancer risk. Meta-analysis of five.

Scatterplots of qMSP analysis of candidate genes promoters in the discovery screen cohort, which consisted of 24 OSCC samples and 12 normal oral cavity.

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Effects of maternal exposure during pregnancy to tap water (control), LIM, or HIM on offspring tumor incidence (% rats with tumors; A), tumor multiplicity.

EPA+DHA supplementation does not alter body composition, body weight, or feed intake. EPA+DHA supplementation does not alter body composition, body weight,

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Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children (n = 50; B). Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children.

Gene copy number analysis by multiplexed quantitative differential PCR for BRCA1 and BRCA2 for 23 DNA specimens obtained from patients of Hispanic ancestry.

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Characterization of DNA-PK and PARP-1 levels and activities in the cell lines studied. Characterization of DNA-PK and PARP-1 levels and activities in the.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

One-way hierarchical cluster analysis of SAM-identified genes using the TMEV software to see the data substructure. One-way hierarchical cluster analysis.

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Progastrin staining in colon adenomas and adenocarcinomas.

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A summary of the average level of methylation of selected MCA/RDA MICPs by bisulfite-modified genomic sequencing. A summary of the average level of methylation.

A, Proportion for different in silico predictions at the RNA level.

The pattern of association between all-cancer mortality risk and long-term exposure to PM2.5 (μg/m3). The pattern of association between all-cancer mortality.

Individuals affected with cancer included in the Lynch syndrome are colored. Individuals affected with cancer included in the Lynch syndrome are colored.

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Quantile–quantile plots of 42 interaction P values for seven SNPs under investigation. Quantile–quantile plots of 42 interaction P values for seven SNPs.

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Scatter plots of the posterior probability values belonging to normal and IM gastric tissue categories calculated by (A) FP; (B) HW; and (C) integrated.

Tobacco-specific carcinogens induce methylation, DNA adducts, DNA damage, and activation of DNMT1. Tobacco-specific carcinogens induce methylation, DNA.

Schematic representation of the HPV genome, highlighting the regions important in PCR-based HPV analysis. Schematic representation of the HPV genome, highlighting.

Epithelial and stromal percentage clusterin staining in normal nonadjacent colonic tissue and matched tumor tissue in 202 patients with stage II colorectal.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

CONSORT diagram. a, 5 had a major treatment violation (3 refused and 2 received wrong treatment) but were included in the analyses; b, 4 had a major treatment.

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Schematic of experimental parameters comparing FFPE DNA repair methods to FF DNA. DNA (500 ng) from FF tissue was processed according to Illumina Human Methylation instructions, including bisulfite modification followed by the standard Human Methylation pro... Schematic of experimental parameters comparing FFPE DNA repair methods to FF DNA. DNA (500 ng) from FF tissue was processed according to Illumina Human Methylation instructions, including bisulfite modification followed by the standard Human Methylation processing protocol (Gold standard). Experimental conditions are separated for REPLI-g ligation (LIG) and Illumina Restore Kit (RES). LIG1: the original Thirwell method using 500 ng of genomic DNA processed by REPLI-g ligase and bisulfite modified (BS), and 4 μL of bisulfite-modified DNA used for the starting material for the Illumina Human Methylation array kit. LIG2: Thirwell method with output DNA increased to 8 μL of bisulfite-modified DNA, which is the same as used in the Restore Kit. LIG3 and LIG4: 500 ng and 250 ng of genomic DNA, respectively, were bisulfite modified, processed by REPLI-g ligase and 8 μL of material used for Illumina Methylation Array kit. RES1: the Illumina Restore protocol using 500 ng of genomic DNA, bisulfite modified, and processed per Restore Kit protocol (including 8 μL for Array steps). RES2 and RES3: technical replicates for Restore Kit using 250 ng of genomic DNA. Erin M. Siegel et al. Cancer Epidemiol Biomarkers Prev 2014;23:2622-2631 ©2014 by American Association for Cancer Research