Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop?

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Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop? Satish Patel, Jim Woodgett Cancer Cell Volume 14, Issue 5, Pages 351-353 (November 2008) DOI: 10.1016/j.ccr.2008.10.013 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Dependence of MLL-Leukemic Cells on GSK-3 Activity for Proliferation The model of Wang et al. (2008) suggests that GSK-3 supports the maintenance of MLL leukemia cells by promoting continuous degradation of the cyclin-dependent kinase inhibitor p27Kip1. Various strategies to inactivate GSK-3 result in stabilization of p27Kip1, which invokes subsequent growth arrest in MLL but not non-MLL leukemic or normal cells. Cancer Cell 2008 14, 351-353DOI: (10.1016/j.ccr.2008.10.013) Copyright © 2008 Elsevier Inc. Terms and Conditions