Median per cent change (error bars represent the quartile ranges Q1–Q3) from baseline in biomarkers of (A) acute-phase response (CRP), (B and C) synovial.

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Presentation transcript:

Median per cent change (error bars represent the quartile ranges Q1–Q3) from baseline in biomarkers of (A) acute-phase response (CRP), (B and C) synovial inflammation (C3M and MMP-3), (D) tissue destruction (C1M), (E) bone resorption (tRANKL) and (F) lymphoid RA synovial phenotype (CXCL13). Median per cent change (error bars represent the quartile ranges Q1–Q3) from baseline in biomarkers of (A) acute-phase response (CRP), (B and C) synovial inflammation (C3M and MMP-3), (D) tissue destruction (C1M), (E) bone resorption (tRANKL) and (F) lymphoid RA synovial phenotype (CXCL13). ANOVA-type method was implemented. *Adjusted P<0.05 versus placebo; **adjusted P<0.01 versus placebo; †adjusted P<0.01 versus sarilumab 150 mg q2w (Benjamini-Hochberg procedure); ‡nominal P<0.0001 versus placebo (CRP only); §nominal P<0.0001 versus sarilumab 150 mg q2w (CRP only). ANOVA, analysis of variance; C1M, collagen type I MMP-cleaved fragment; C3M, collagen type III MMP-cleaved fragment; CRP, C-reactive protein; csDMARD, conventional synthetic disease-modifying antirheumatic drug; CXCL13, chemokine, CXC motif, ligand 13; MMP, matrix metalloproteinase; q2w, every 2 weeks; RA, rheumatoid arthritis; tRANKL, total receptor activator of nuclear factor-κB ligand. Cem Gabay et al. RMD Open 2018;4:e000607 Copyright © BMJ Publishing Group & EULAR. All rights reserved.