Fig. 1 A time-course RNA-seq analysis reveals prominent IRF8 expression in the spinal cord during the recovery phase after SCI. A time-course RNA-seq analysis.

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Fig. 1 A time-course RNA-seq analysis reveals prominent IRF8 expression in the spinal cord during the recovery phase after SCI. A time-course RNA-seq analysis reveals prominent IRF8 expression in the spinal cord during the recovery phase after SCI. (A) A heat map showing gene expression changes in the injured cord at 4, 7, and 14 dpi. Data from the samples of injured cords were normalized to those of uninjured cords. (B) GO term analysis of overexpressed (>10-fold change) genes in the RNA-seq analysis of the injured cord (7 dpi) compared to those of the uninjured cord. Lists show the top nine GO terms obtained ranked by P value (Fisher’s exact test with Benjamini-Hochberg correction). (C) Volcano plot of the gene expression differences between the injured cord (7 dpi) and uninjured cord. Red or blue dots indicate significantly up-regulated or down-regulated genes, respectively. (D) Wiggle plots showing the coverage of each exon for IRF8 before injury and at 4, 7, and 14 dpi. Ref-seq, reference sequencing. (E) Ratio of the fragments per kilobase of exon per million mapped sequence reads (FPKM) value of IRF8 to the mean FPKM value of all expressed genes at each time point after SCI. (F) Significantly increased mRNA expression of IRF8 analyzed with qPCR in spinal cords before and after injury (n = 5 per each time point). The data shown in (A) to (E) are representative of four samples per time point. *P < 0.05 and **P < 0.001, one-way analysis of variance (ANOVA) with Dunnett’s test for multiple comparisons against the uninjured control group (F). The data are presented as the means ± SEM. Kazu Kobayakawa et al. Sci Adv 2019;5:eaav5086 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).