Efficacy of BP2 in treatment of biomaterial-associated S

Slides:

Advertisements

Similar presentations

Frequency of COP cells in control mice (caALK2) #1#2#3#4Average (%) Baseline (WT) undetectable Baseline (caALK2) 0.25 Day Day

Advertisements

Supplemental Figures CAN Sahu et al.. Fig Supplementary S1 Figure S1. Chemotherapy agents generate PAF-R agonist formation in human SK23MEL melanoma.

Two Categorical Variables: The Chi-Square Test

(B.P :51) ( B:P52 ).

Comparison of prevalence of uncovered struts between ZES and EES groups. Comparison of prevalence of uncovered struts between ZES and EES groups. Scatter plot.

Volume 54, Issue 3, Pages (September 2008)

Treatment with p38γ/p38δ inhibitor shows antifungal effects in vivo

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Survival of mice after infection with M

Fig. 4 Topical application of SAAP-148 ointment eradicates acute and established infections of MRSA and A. baumannii from the skin. Topical application.

Fig. 1 ZIKV-related flaviviruses cause fetal demise in mice that can be prevented by mAb treatment. ZIKV-related flaviviruses cause fetal demise in mice.

Fig. 4. In vivo analysis of slpA mutant in the Syrian Golden hamster.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Cocaine exposure downregulates miR-125b expression.

Suntanu Dalal, MSc, Ronald Melzack, PhD

Expression characterizations of PARK2.

Nikole J. Byrne et al. BTS 2017;j.jacbts

Fig. 7 BRD0705 impairs colony formation in AML cell lines and patient cells and shows in vivo efficacy in multiple AML mouse models. BRD0705 impairs colony.

Fig. 4 DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft tumor models. DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft.

Antitumor effects of FF and gemcitabine on two pancreatic PDX models.

Comparison of therapeutic efficacies of C12G6 and other bnAbs in mice

Association of cryptococci with the brain endothelium requires Mpr1 in the tail-vein murine model. Association of cryptococci with the brain endothelium.

Effect of route of administration (i.v. versus i.p.).

Fig. 7. mRIPO therapy restricts tumor growth and produces antigen-specific antitumor immunity. mRIPO therapy restricts tumor growth and produces antigen-specific.

Fig. 4. Efficacy of C12G6 compared with and in combination with oseltamivir in mice. Efficacy of C12G6 compared with and in combination with oseltamivir.

Reduction of neutrophil airspace influx does not significantly attenuate alveolar barrier disruption in thrombocytopenic Mpl−/− mice following either live.

Fig. 4 Surgery initiates a systemic inflammatory response that triggers the outgrowth of distant immunogenic tumors and can be inhibited by perioperative.

Influence of PDR1 hyperactivity and EPA1 on the colonization of the bladder and kidney by C. glabrata in the murine urinary tract infection (UTI) model.

A, Comparison of cortisol levels between the nonintervention group (n = 94) and the intervention group (n = 104). A, Comparison of cortisol levels between.

Pharmacologic inhibitors of PI3Kγ suppress PDAC growth and metastasis.

Figure 1 BG-12 treatment reduced total circulating B cells and had variable effects on memory B cells BG-12 treatment reduced total circulating B cells.

AN12855 is efficacious in acute and chronic murine models of TB infection. AN12855 is efficacious in acute and chronic murine models of TB infection. (A,

Azithromycin treatment eliminates NTHi infection.

Pharmacokinetics and efficacy of AZD8848 in the Brown Norway rat.

Effects of tumour size on response to treatment in the KPC model.

Ability of C. muridarum with or without mutations in tc0668 and/or tc0237 to induce hydrosalpinx in C3H/HeJ mice following intravaginal inoculation. Ability.

Therapeutic delivery of rhIGF-1 reduces the severity of contact hypersensitivity responses. Therapeutic delivery of rhIGF-1 reduces the severity of contact.

Human cathelicidin LL37 killing assays (2 h) at 1× MIC for daptomycin-susceptible (left) and -nonsusceptible (right) VRE strains after growth in media.

MRP2 inhibition mitigates pulmonary burden and bacteremia following lung challenge with S. pneumoniae. MRP2 inhibition mitigates pulmonary burden and bacteremia.

Figure 1 EAE severity and CNS pathology in Dex-treated MIF−/− and Wt mice Wild-type (Wt) and macrophage migration inhibitory factor (MIF)−/− mice were.

CPI-444 efficacy requires CD8+ T cells and is associated with increased CD73 expression. CPI-444 efficacy requires CD8+ T cells and is associated with.

MSHA is crucial for colonization of C. elegans by V. cholerae.

Efficacy of BP2 in prophylaxis against biomaterial-associated S

Effects of rhein on FBG (A) and glucose intolerance (B) in db/db mice.

Enrichment of KEGG pathways in microbial genes in different samples.

Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model in vivo. Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model.

In vivo efficacy and specificity of OTL78 in orthotopic and subcutaneous tumor models using the AMI image system. In vivo efficacy and specificity of OTL78.

Functional characterization of multidonor class antibodies.

Effect of therapy with S247 on the development of liver metastases after 14 and 21 days of tumor growth. Effect of therapy with S247 on the development.

Pharmacological targeting of CDs promotes response to KRASG12C inhibition in vivo. Pharmacological targeting of CDs promotes response to KRASG12C inhibition.

Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth and metastasis. Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth.

Simvastatin does not correct AGS in the Fmr1-/y mouse.

B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling.

Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.

Flowchart demonstrating the outcomes for MRSA-positive individuals after the first detection of MRSA. Unsuccessful treatment was defined as one or more.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Wild-type mice weight following 6-thio-dG and 6-thioguanine treatment.

SPARC is required for spontaneous metastasis

Efficacy of KM100 and/or MTX in BALB/c mice bearing subcutaneous TUBO tumors. Efficacy of KM100 and/or MTX in BALB/c mice bearing subcutaneous TUBO tumors.

Phage activity against Pseudomonas aeruginosa (LESB65 wild type and adapted strain NP22_2) infection in the murine lung. Phage activity against Pseudomonas.

GCS-100 selectively kills KRAS-addicted lung tumors.

Colonization with B. fragilis protects mice against development of colon cancer. Colonization with B. fragilis protects mice against development of colon.

Multiplicity of colonic microadenomas and colon tumour incidence in Apc+/Min-FCCC mice, following drug exposure. Multiplicity of colonic microadenomas.

ARQ 531 improves survival in the Eμ-TCL1 engraftment model compared with ibrutinib. ARQ 531 improves survival in the Eμ-TCL1 engraftment model compared.

Depletion of CD8+, CD4+, and Ly6G+ cells in subcutaneous TUBO tumor-bearing BALB/c mice treated with KM100 + MTX. Depletions were conducted by intraperitoneal.

NSD2-mediated methylation of PTEN at K349 dictates cellular sensitivity to DNA-damaging agents. NSD2-mediated methylation of PTEN at K349 dictates cellular.

Comparison of C. muridarum organisms with or without a deficiency in pGP3 for their ability to induce hydrosalpinx in the upper genital tract and spread.

Parthenolide inhibits tumor promotion and increases p21 expression in vivo. Parthenolide inhibits tumor promotion and increases p21 expression in vivo.

(a) MIC distribution for the novel pleuromutilin lefamulin and the macrolide azithromycin, including clinical Neisseria gonorrhoeae isolates (n=217) and.

Presentation transcript:

Efficacy of BP2 in treatment of biomaterial-associated S Efficacy of BP2 in treatment of biomaterial-associated S. epidermidis infection. Efficacy of BP2 in treatment of biomaterial-associated S. epidermidis infection. One hour after implantation of biomaterials and challenge with 106 CFU of S. epidermidis RP62a, mice received an injection of 50 μl saline or BP2 (5 mg/kg) subcutaneously along each implant. Mice were sacrificed after 24 h, and numbers of CFU adherent to the implants and present in peri-implant tissue were assessed. Two-sample comparisons were made using a two-tailed Mann-Whitney rank sum test. The significance of differences between the frequencies of categorical variables was determined using Fisher's exact test. Paulus H. S. Kwakman et al. Antimicrob. Agents Chemother. 2006; doi:10.1128/AAC.00575-06