The presence of soluble IL12p70 during moDCpoly stimulation of KIRnegNKG2Aneg cells results in a dominant population of multifunctional NKG2Apos NK cells.

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The presence of soluble IL12p70 during moDCpoly stimulation of KIRnegNKG2Aneg cells results in a dominant population of multifunctional NKG2Apos NK cells. The presence of soluble IL12p70 during moDCpoly stimulation of KIRnegNKG2Aneg cells results in a dominant population of multifunctional NKG2Apos NK cells. Pooled data illustrating percentage of CD107apos (A) or IFNγpos NK cells (B) that express either NKG2A (mean ± SD; n = 7) or KIR (mean ± SD; n = 4) following 6 days of DC stimulation. Asterisks above error bars indicate statistical differences between NKG2Apos and KIRpos cells for that condition, whereas notations above the brackets refer to the indicated comparisons between conditions. **, P = 0.001–0.01; ****, P ≤ 0.0001; ns, not statistically significant. Shane A. Curran et al. Cancer Immunol Res 2014;2:1000-1010 ©2014 by American Association for Cancer Research