Treatment with R848 and anti-CD200R leads to changes in the composition of intratumor myeloid cells. Treatment with R848 and anti-CD200R leads to changes.

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Anti-CD40 and CpG induce activation of T cells in draining lymph nodes

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Identification of combination treatment–responsive dysfunctional tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

by Venetia Bigley, Laura E. Spence, and Matthew Collin

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Presentation transcript:

Treatment with R848 and anti-CD200R leads to changes in the composition of intratumor myeloid cells. Treatment with R848 and anti-CD200R leads to changes in the composition of intratumor myeloid cells. Fractions of intratumor myeloid cells (CD11b+). A, Ly6ChiMHC-II− monocytes; B, immature macrophages (MHC-II− Imm Mφ); C, Ly6Chi/intMHC-II+ immature macrophages (MHC-II+ Imm Mφ); D, Ly6C−MHC-II− TAMs (MHC-II− TAM); E, Ly6C−MHC-II+ TAMs (MHC-II+TAM). F, Example scatterplots of intratumoral myeloid cells showing gating for all above populations, from all treatment groups. A–F, Reproduced two times. When not indicated otherwise, significance was calculated in comparison with the PBS-only control group using one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Zofia Pilch et al. Cancer Immunol Res 2018;6:930-940 ©2018 by American Association for Cancer Research